AKAP5 anticorps (AA 180-427)

N° du produit ABIN967900

Détail du produit anti-AKAP5 anticorps

Antigène: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Épitope: AA 180-427

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AKAP5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human AKAP79 aa. 180-427

Clone: 22-AKAP79

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968552, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-AKAP5 (ABIN967900)

Schillace, Andrews, Liberty, Davey, Carr: "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1590-9, (2002) (PubMed).

Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).

Coghlan, Perrino, Howard, Langeberg, Hicks, Gallatin, Scott: "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein." dans: Science (New York, N.Y.), Vol. 267, Issue 5194, pp. 108-11, (1995) (PubMed).

Carr, Stofko-Hahn, Fraser, Cone, Scott: "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79." dans: The Journal of biological chemistry, Vol. 267, Issue 24, pp. 16816-23, (1992) (PubMed).

Détails sur AKAP5

Antigène: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Autre désignation: AKAP79 (AKAP5 Produits)

Synonymes: anticorps AKAP5, anticorps AKAP75, anticorps AKAP79, anticorps H21, anticorps AKAP, anticorps P75, anticorps 3526401B18Rik, anticorps AKAP 150, anticorps AKAP-5, anticorps AKAP150, anticorps BB098886, anticorps Gm258, anticorps P150, anticorps Akap79, anticorps A kinase (PRKA) anchor protein 5, anticorps A-kinase anchoring protein 5, anticorps AKAP5, anticorps Akap5

Classe de substances: Viral Protein

Sujet: The type II cAMP-dependent Protein Kinase (PKA) is compartmentalized within the cell. To maintain this localization of type II PKAs, the regulatory subunit (RII) interacts with specific RII-anchoring proteins. For instance, attachment of type II PKA to the cytoskeleton occurs through the binding of RII to microtubule-associated protein 2 (MAP2). In brain, several proteins have been identified as PKA type II anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). AKAP79 is a 79kDa human RII-anchoring protein. AKAP, PKA type II, and calcineurin (PP2B) can form a tertiary complex, suggesting that both PKA and calcineurin are targeted by a common protein to subcellular sites where they regulate the phosphorylation status of key substrates.

Poids moléculaire: 79 kDa

Pathways: cAMP Metabolic Process