SSB anticorps (AA 179-289)

N° du produit ABIN968242

Détail du produit anti-SSB anticorps

Antigène: SSB (Sjogren Syndrome Antigen B (SSB))

Épitope: AA 179-289

Reactivité: Humain, Rat, Chien, Lapin

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SSB est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Humain, Chien, Lapin, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human La Protein aa. 179-289

Clone: 44-La Protein

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968551, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-SSB (ABIN968242)

Goodier, Fan, Maraia: "A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein." dans: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5823-32, (1997) (PubMed).

McLaren, Caruccio, Ross: "Human La protein: a stabilizer of histone mRNA." dans: Molecular and cellular biology, Vol. 17, Issue 6, pp. 3028-36, (1997) (PubMed).

Chambers, Kenan, Martin, Keene: "Genomic structure and amino acid sequence domains of the human La autoantigen." dans: The Journal of biological chemistry, Vol. 263, Issue 34, pp. 18043-51, (1989) (PubMed).

Détails sur SSB

Antigène: SSB (Sjogren Syndrome Antigen B (SSB))

Autre désignation: La Protein (SSB Produits)

Synonymes: anticorps LARP3, anticorps La, anticorps lab1, anticorps larp3, anticorps ssb, anticorps Mt-SSB, anticorps MtSSB, anticorps Ssbp1, anticorps SS-B, anticorps laa-a, anticorps ssb-a, anticorps ssb-b, anticorps wu:fb17f11, anticorps zgc:55588, anticorps Sjogren syndrome antigen B, anticorps Sjogren syndrome antigen B L homeolog, anticorps single stranded DNA binding protein 1, anticorps Sjogren syndrome antigen B S homeolog, anticorps Sjogren syndrome antigen B (autoantigen La), anticorps SSB, anticorps ssb.L, anticorps SSBP1, anticorps Ssb, anticorps ssb.S, anticorps ssb

Sujet: La was first found to bind autoantibodies from individuals with Sjogren's syndrome and systemic lupus erythematosus (SLE). La is a transcription factor for RNA polymerase III (Pol III). It participates in the termination of Pol III-mediated transcription and the recycling of the transcriptional machinery. La associates with the 3' oligo U portion of transcripts generated by Pol III. In some cases, this association protects the message from 3' processing. The association of La and mRNA is mediated by the presence of an N-terminal ribonucleoprotein (RNP) consensus sequence in La. The La protein also binds several small RNAs, such as 7S RNA, 5S RNA, and tRNA, and is thought to be involved in their biogenesis. It is known that histone mRNA is stabilized throughout S Phase and is degraded only at the end of S phase. La protein participates in the stabilization of histone mRNA which results in increased production of histone protein. These data suggest that a major function of La is to protect vital nascent transcripts from premature degradation.

Poids moléculaire: 47 kDa