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LIMS1 anticorps (AA 120-220)

LIMS1 Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IF Hôte: Souris Monoclonal 49-PINCH unconjugated
N° du produit ABIN968921
  • Antigène Voir toutes LIMS1 Anticorps
    LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
    Épitope
    • 15
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 120-220
    Reactivité
    • 59
    • 24
    • 16
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 49
    • 10
    Souris
    Clonalité
    • 49
    • 10
    Monoclonal
    Conjugué
    • 20
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LIMS1 est non-conjugé
    Application
    • 19
    • 13
    • 13
    • 13
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Souris
    Aucune reactivité croisée
    Chien, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human PINCH aa. 120-220
    Clone
    49-PINCH
    Isotype
    IgG2a
    Top Product
    Discover our top product LIMS1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968586, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Campana, Myers, Rearden: "Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury." dans: Glia, Vol. 41, Issue 3, pp. 213-23, (2003) (PubMed).

    Tu, Li, Goicoechea, Wu: "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells." dans: Molecular and cellular biology, Vol. 19, Issue 3, pp. 2425-34, (1999) (PubMed).

    Tu, Li, Wu: "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways." dans: Molecular biology of the cell, Vol. 9, Issue 12, pp. 3367-82, (1999) (PubMed).

  • Antigène
    LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
    Autre désignation
    PINCH (LIMS1 Produits)
    Synonymes
    anticorps PINCH, anticorps PINCH-1, anticorps PINCH1, anticorps Pinch1, anticorps RGD1560732, anticorps LIMS3, anticorps LIMS3L, anticorps 2310016J22Rik, anticorps 4921524A02Rik, anticorps AI507642, anticorps AU021743, anticorps AW551584, anticorps C430041B13Rik, anticorps Lims1l, anticorps LIM zinc finger domain containing 1, anticorps LIM and senescent cell antigen-like domains 1, anticorps LIMS1, anticorps Lims1
    Sujet
    Integrins are transmembrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are heterodimers composed of alpha and beta subunits, which interact with extracellular matrix and cytoskeletal proteins. Signal transduction through intergin receptors may be regulated by integrin-linked kinase (ILK). ILK is a widely expressed Ser/Thr protein kinase that contains four ankyrin-like repeats in the N-terminal region, a phoshoinositide lipid-binding motif at amino acids 180-212, and an integrin binding site at amino acids 293-451. The ankyrin repeats interact with a LIM domain-only protein called PINCH that also binds the adaptor protein, Nck-2. This interaction implicates ILK in growth factor receptor pathways. The PINCH adaptor protein also contains a leucine-rich nuclear export signal and a nuclear localization signal. These two motifs implicate PINCH in nuclear functions, and in Schwann cells PINCH has been found in the nucleus, as well as, cytoplasm and perinuclear regions. Thus, PINCH is an adaptor protein that functions in both integrin signaling and nuclear functions.
    Poids moléculaire
    37 kDa
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