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Aperçu des produits pour anti-CLOCK (CLOCK) Anticorps

Full name:
anti-Clock Homolog (Mouse) Anticorps (CLOCK)
Chez www.anticorps-enligne.fr sont 117 Clock Homolog (Mouse) (CLOCK) Anticorps de 21 de différents fournisseurs disponibles. De plus, nous expédions CLOCK Kits (7) et CLOCK Protéines (5) et beaucoup plus de produits pour cette protéine. Un total de 137 CLOCK produits sont actuellement listés.
Synonymes:
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1

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anti-CLOCK Anticorps mieux référencés

  1. Human Polyclonal CLOCK Primary Antibody pour ChIP, WB - ABIN151057 : Jin, Shearman, Weaver, Zylka, de Vries, Reppert: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. dans Cell 1999 (PubMed)
    Show all 6 references for ABIN151057

  2. Human Polyclonal CLOCK Primary Antibody pour EIA, IHC (p) - ABIN359753 : Marino, Holt, Chen, Davis: Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. dans Epidemiology (Cambridge, Mass.) 2008 (PubMed)
    Show all 3 references for ABIN359753

  3. Human Monoclonal CLOCK Primary Antibody pour ICC, ELISA - ABIN969059 : Lee, Paik, Kang, Lim, Kim: Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. dans Chronobiology international 2007 (PubMed)
    Show all 2 references for ABIN969059

  4. Human Polyclonal CLOCK Primary Antibody pour ELISA, WB - ABIN564129 : Kalamvoki, Roizman: Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. dans Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  5. Human Polyclonal CLOCK Primary Antibody pour IHC, ELISA - ABIN1533501 : Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. dans Genomics 1999 (PubMed)

Plus d’anticorps contre CLOCK partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (Montrer COX6C Anticorps) E-box binding, thus enhancing the removal of CLK-CYC (Montrer COX6C Anticorps) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (Montrer COX6C Anticorps) from E-boxes

  2. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  3. Our findings suggest a novel role for clock protein (Montrer ARNTL Anticorps) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  4. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  5. Computational dissection of CLK/CYC (Montrer COX6C Anticorps) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  6. usp8 (Montrer USP8 Anticorps) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (Montrer USP8 Anticorps)-DN) enhances CLK/CYC (Montrer COX6C Anticorps) transcriptional activity and alters fly locomotor activity rhythms

  7. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  8. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  9. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  10. findings show that Clk and cyc (Montrer COX6C Anticorps) act during starvation to modulate the conflict of whether flies sleep or search for food

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. effect of CRY (Montrer CRY2 Anticorps) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (Montrer GC Anticorps) gene by targeting BMAL1 (Montrer ARNTL Anticorps) and CLOCK.

  2. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1 (Montrer ARNTL Anticorps):CLOCK to conserved DNA elements

  3. RNA interference screens reveal the heterodimeric, circadian rhythm Transcription factors Clock and Bmal1 (Montrer ARNTL Anticorps) as genes required for the growth of acute myeloid leukemia (Montrer BCL11A Anticorps) cells in vitro and in vivo.

  4. Findings indicate that CLOCK protein (Montrer ARNTL Anticorps) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  5. Irp2 (Montrer IREB2 Anticorps) mRNA transcription is promoted by circadian clock genes, including BMAL1 (Montrer ARNTL Anticorps), and the CLOCK heterodimer.

  6. In CLOCK-deficient fibroblasts, knockdown of Npas2 (Montrer NPAS2 Anticorps) leads to arrhythmicity, suggesting that NPAS2 (Montrer NPAS2 Anticorps) can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.

  7. SERPINA3K is involved in the Clock gene-mediated male fertility by regulating acrosin (Montrer ACR Anticorps) activity and provide the first evidence that SERPINA3K could be regulated by Clock gene via retinoic acid-related orphan receptor (Montrer NR1D2 Anticorps) response elements.

  8. Circadian CLOCK Mediates Activation of Transforming Growth Factor-beta Signaling and Renal Fibrosis through Cyclooxygenase 2 (Montrer PTGS2 Anticorps).

  9. Propose that USF1 (Montrer USF1 Anticorps) is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex.

  10. Clock is a novel regulator of psoriasis-like skin inflammation in mice via direct modulation of IL-23R (Montrer IL23R Anticorps) expression in gamma/delta+ T cells

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  2. Immunostaining of CLOCK and PER2 (Montrer PER2 Anticorps) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (Montrer PER2 Anticorps) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  3. possible circadian rhythm in full-term placental expression

  4. Findings indicate that CLOCK protein (Montrer ARNTL Anticorps) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  5. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  6. when overexpressed, c-MYC (Montrer MYC Anticorps) is able to repress Per1 (Montrer PER1 Anticorps) transactivation by BMAL1 (Montrer ARNTL Anticorps)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (Montrer MYC Anticorps) was detected in BMAL1 (Montrer ARNTL Anticorps) protein complexes

  7. CLOCK, ARNTL (Montrer ARNTL Anticorps), and NPAS2 (Montrer NPAS2 Anticorps) gene polymorphisms may have a role in seasonal variations in mood and behavior

  8. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  9. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (Montrer ARNTL Anticorps) by CBP (Montrer CREBBP Anticorps) for immediate-early (Montrer JUN Anticorps) Per induction and the resetting of the circadian clock.

  10. the circadian gene hClock promoted CRC (Montrer CALR Anticorps) progression and inhibit tumor cell apoptosis in vitro and in vivo, while silencing hClock was able to reverse this effect.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (Montrer CRY2 Anticorps) is important for repression through facilitating interaction with CLOCK

CLOCK profil antigène

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk) anticorps
  • clock homolog (mouse) (CLOCK) anticorps
  • clock circadian regulator (clock) anticorps
  • clock homolog (CLOCK) anticorps
  • clock (clock) anticorps
  • circadian locomotor output cycles kaput (Clock) anticorps
  • clock circadian regulator (Clock) anticorps
  • clock circadian regulator (CLOCK) anticorps
  • 5330400M04Rik anticorps
  • bHLHe8 anticorps
  • bHLHe10 anticorps
  • CG7391 anticorps
  • clk anticorps
  • clock anticorps
  • dClck anticorps
  • dclk anticorps
  • dCLK/JRK anticorps
  • dClock anticorps
  • Dmel\\CG7391 anticorps
  • Jerk anticorps
  • jrk anticorps
  • KAT13D anticorps
  • mKIAA0334 anticorps
  • PAS1 anticorps
  • Xclk anticorps
  • XClock anticorps
  • zCLOCK1 anticorps
  • zfCLOCK1 anticorps

Protein level used designations for CLOCK

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

GENE ID SPECIES
38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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