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Chicken Monoclonal SREBF2 Primary Antibody pour ELISA, GS - ABIN4355936
Janowski, Shan, Russell: The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. dans The Journal of biological chemistry 2001
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Human Polyclonal SREBF2 Primary Antibody pour ICC, IF - ABIN261631
Huster, Purnat, Burkhead, Ralle, Fiehn, Stuckert, Olson, Teupser, Lutsenko: High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. dans The Journal of biological chemistry 2007
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Human Monoclonal SREBF2 Primary Antibody pour IP, WB - ABIN967564
Hua, Sakai, Ho, Goldstein, Brown: Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. dans The Journal of biological chemistry 1996
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Human Monoclonal SREBF2 Primary Antibody pour ChIP, WB - ABIN2668815
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. dans PLoS ONE 2014
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Human Polyclonal SREBF2 Primary Antibody pour IP, WB - ABIN4355938
Karanth, Tran, Kuberan, Schlegel: Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. dans Disease models & mechanisms 2013
Data, including data from studies using transgenic mice, suggest that oligodendroglial myelination requires astrocyte-derived lipids; oligodendrocyte-specific inactivation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential factor in lipid biosynthesis along with SREBP2, results in significantly retarded CNS myelination.
The findings suggest that Cyp3a deficiency stimulated the expression of Scap via activation of the AR, which elevated cholesterogenic gene expression levels through activation of SREBP2 and increased total cholesterol contents in the prostate.
SIRT1 (Montrer SIRT1 Anticorps) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (Montrer AKT1 Anticorps) signalling pathway, suggesting that SIRT1 (Montrer SIRT1 Anticorps) gene may play a protective role against osteoarthritis.
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (Montrer NGFR Anticorps) that via p38 MAPK (Montrer MAPK14 Anticorps) and caspase-3 (Montrer CASP3 Anticorps) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (Montrer NGFB Anticorps) and pro-NGF (Montrer NGFB Anticorps).
This study reveals SHP (Montrer LAMC1 Anticorps) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (Montrer FGF19 Anticorps).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (Montrer SIRT6 Anticorps) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (Montrer APOE Anticorps) null mice
SREBP2-induced miR (Montrer MLXIP Anticorps)-92a targets key molecules in endothelial homeostasis, including sirtuin 1 (Montrer SIRT1 Anticorps), Kruppel-like factor 2, and Kruppel-like factor 4 (Montrer KLF4 Anticorps), leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase (Montrer NOS3 Anticorps) inhibition.
The cholesterol-lowering effects of FGF21 (Montrer FGF21 Anticorps) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Date indicate that sterol regulatory element-binding proteins Srebp1 (Montrer SREBF1 Anticorps) and Srebp2 are essential for the metabolic reprogramming of NK cells and for the attainment of elevated glycolysis and oxidative phosphorylation.
SREBP-1 (Montrer SREBF1 Anticorps) and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (Montrer CAD Anticorps) (26 with diabetes) and 23 controls without CAD (Montrer CAD Anticorps) or diabetes.SREBP expression was associated as cardiovascular risk factor for the severity of CAD (Montrer CAD Anticorps) and the poor lipid control.
High expression of SREBF2 is associated with high carotid intima-media thickness.
mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR (Montrer ELAVL1 Anticorps) circuit, although the deficiency triggers transient pro-inflammatory signals.
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.
Data show that mutant p53 protein (Montrer TP53 Anticorps) activates the sterol regulatory element-binding proteins SREBP-1 (Montrer SREBF1 Anticorps) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (Montrer FLVCR1 Anticorps)) cells.
The connections of EGFR (Montrer EGFR Anticorps) and ERBB4 (Montrer ERBB4 Anticorps) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (Montrer EGFR Anticorps)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (Montrer EGFR Anticorps)-driven cancers.
Akt1 (Montrer AKT1 Anticorps) and Akt2 (Montrer AKT2 Anticorps) activated both SREBP-1 (Montrer SREBF1 Anticorps) and SREBP-2, whereas Akt3 (Montrer AKT3 Anticorps) upregulated SREBP-1 (Montrer SREBF1 Anticorps) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (Montrer Acsl1 Anticorps) mRNA and protein levels.
dysregulation of SIRT1 (Montrer SIRT1 Anticorps)-AMPK (Montrer PRKAA1 Anticorps)-SREBP and stimulation of NLRP3 (Montrer NLRP3 Anticorps) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (Montrer KLF13 Anticorps) and SREBP-Sp1 (Montrer SP1 Anticorps) activation interact to regulate low density lipoprotein receptor (Montrer LDLR Anticorps) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2