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Results suggest that calnexin is essential for neuromast formation during lateral line development.
Increased tumour protein levels of calnexin may be of prognostic significance in colorectal cancer, and calnexin may represent a potential target for future therapies.
FUNDC1 (Montrer FUNDC1 Kits ELISA) integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (Montrer CRMP1 Kits ELISA) and calnexin under hypoxic conditions in mammalian cells.
Results of further analyses by using a CNX mutant imply that ERp29 (Montrer ERP29 Kits ELISA) and ERp57 (Montrer PDIA3 Kits ELISA) recognize the same domain of CNX, whereas the mode of interaction with CNX might be somewhat different between them.
Inhibit interaction between HIV-1 Nef and Calnexin to reverse HIV-induced lipid accumulation and prevent atherosclerosis.
Endogenous NOX4 (Montrer NOX4 Kits ELISA) forms macromolecular complexes with calnexin, which are needed for the proper maturation, processing, and function of NOX4 (Montrer NOX4 Kits ELISA) in the endoplasmic reticulum.
To study principles underlying dynamics and regulation of palmitoylation, the ER chaperone calnexin, which requires dual palmitoylation for function, was investigated.
These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 (Montrer NMT1 Kits ELISA) at the ER membrane.
Charcot-Marie-Tooth disease-related PMP22 (Montrer PMP22 Kits ELISA) is trapped in the endoplasmic reticulum by calnexin-dependent retention and Rer1 (Montrer RER1 Kits ELISA)-mediated early Golgi retrieval systems and partly degraded by the Hrd1 (Montrer SYVN1 Kits ELISA)-mediated endoplasmic reticulum-associated degradation system.
Data indicate that protein tyrosine phosphatase 1B (PTP1B (Montrer PTPN1 Kits ELISA)) association with calnexin is ubiquitin conjugating enzyme 9 (UBC9 (Montrer UBE2I Kits ELISA))-dependent.
H-ERG (Montrer KCNH2 Kits ELISA) trafficking was impaired by H2O2 after 48 h treatment, accompanied by reciprocal changes of expression between miR-17-5p seed miRNAs and several chaperones (Hsp70 (Montrer HSP70 Kits ELISA), Hsc70 (Montrer HSPA8 Kits ELISA), CANX, and Golga20)
CNX has a specific role in cardiomyocyte viability and Ca(2 (Montrer CA2 Kits ELISA)+) cycling through its effects on endoplasmic reticulum stress, apoptosis and Ca(2 (Montrer CA2 Kits ELISA)+) channel expression.
Calnexin discriminates between different conformational states of GlyT2 displaying a lectin-independent chaperone activity.
calnexin and ERp57 (Montrer PDIA3 Kits ELISA), but not calreticulin (Montrer CALR Kits ELISA), play an important role in the biology of peripheral myelin proteins PMP22 (Montrer PMP22 Kits ELISA) and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies
Enhanced clathrin-dependent endocytosis in the absence of calnexin may contribute to the neurological phenotype of calnexin-deficient mice
Data show that the E351 mutation led to slightly enhanced ERp57 (Montrer PDIA3 Kits ELISA) binding to calnexin, whereas W428 greatly enhanced binding of ERp57 (Montrer PDIA3 Kits ELISA) to calnexin.
Suggest that Adam7 (Montrer ADAM7 Kits ELISA) functions in fertilization through the formation of a complex with heat shock protein 5 (Montrer HSPA5 Kits ELISA), calnexin and Itm2b (Montrer ITM2B Kits ELISA) during capacitation in sperm.
endoplasmic reticulum stress has effects on group VIA phospholipase A2 (Montrer YWHAZ Kits ELISA) in beta cells that include tyrosine phosphorylation and increased association with calnexin
Calnexin deficiency leads to dysmyelination
Data give novel evidence that CyCAP (Montrer LGALS3BP Kits ELISA) regulates the post-translational modification of tissue transglutaminase (Montrer TGM2 Kits ELISA) through its colocalization with calnexin in endoplasmic reticulum.
Association with mutant peripheral myelin protein-22 (Montrer PMP22 Kits ELISA) ex vivo: a basis for "gain-of-function" ER diseases.
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.
major histocompatibility complex class I antigen-binding protein p88
, calnexin 99A
, hypothetical protein