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Aperçu des produits pour anti-CHEK1 (CHEK1) Anticorps

Full name:
anti-Checkpoint Kinase 1 Anticorps (CHEK1)
Chez www.anticorps-enligne.fr sont 469 Checkpoint Kinase 1 (CHEK1) Anticorps de 29 de différents fournisseurs disponibles. De plus, nous expédions CHEK1 Kits (25) et CHEK1 Protéines (18) et beaucoup plus de produits pour cette protéine. Un total de 552 CHEK1 produits sont actuellement listés.
Synonymes:
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093

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anti-Human CHEK1 Anticorps:

anti-Mouse (Murine) CHEK1 Anticorps:

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anti-CHEK1 Anticorps mieux référencés

  1. Human Polyclonal CHEK1 Primary Antibody pour EIA, IHC (p) - ABIN358109 : Krämer, Mailand, Lukas, Syljuåsen, Wilkinson, Nigg, Bartek, Lukas: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. dans Nature cell biology 2004 (PubMed)
    Show all 5 references for ABIN358109

  2. Human Polyclonal CHEK1 Primary Antibody pour EIA, IHC (p) - ABIN358108 : Xu, Lee, Stern: Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. dans The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN358108

  3. Human Polyclonal CHEK1 Primary Antibody pour EIA, WB - ABIN357628 : Chen, Ryan, Piwnica-Worms: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. dans Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for ABIN357628

  4. Human Polyclonal CHEK1 Primary Antibody pour IHC (p), WB - ABIN389542 : Ng, Lee, Ho, Arooz, Siu, Lau, Poon: Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. dans The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN389542

  5. Human Polyclonal CHEK1 Primary Antibody pour IF, ELISA - ABIN1531555 : Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. dans Science (New York, N.Y.) 1997 (PubMed)
    Show all 2 references for ABIN1531555

  6. Human Polyclonal CHEK1 Primary Antibody pour IF, ELISA - ABIN1531554 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. dans Science (New York, N.Y.) 2007 (PubMed)
    Show all 2 references for ABIN1531554

  7. Cow (Bovine) Polyclonal CHEK1 Primary Antibody pour IHC, WB - ABIN2779737 : Bennett, Larkin, Gillespie, Clarke: Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1. dans Biochemical and biophysical research communications 2008 (PubMed)

Plus d’anticorps contre CHEK1 partenaires d’interaction

Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. HPV31 regulates RRM2 (Montrer RRM2 Anticorps) levels through expression of E7 and activation of the ATR (Montrer ANTXR1 Anticorps)-Chk1-E2F1 (Montrer E2F1 Anticorps) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  2. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  3. revealed more than 170 NFAT (Montrer NFATC1 Anticorps)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (Montrer NFATC1 Anticorps) and NFATc2 (Montrer NFAT1 Anticorps) in T cells, such as Raptor (Montrer RPTOR Anticorps), CHEK1, CREB1 (Montrer CREB1 Anticorps), RUNX1 (Montrer RUNX1 Anticorps), SATB1 (Montrer SATB1 Anticorps), Ikaros (Montrer IKZF1 Anticorps), and Helios (Montrer ZNFN1A2 Anticorps).

  4. Checkpoint kinase 1 and 2 signaling is important for apoptin regulation.

  5. Genetic variants of the CHEK1 gene are significantly related to overall survival and disease-free survival of esophageal squamous cell carcinoma patients.

  6. Role of the CHK1-RAD51 (Montrer RAD51 Anticorps) signaling pathway in osteosarcoma cells.

  7. High CHK1 expression is associated with increased radioresistance of non-small cell lung cancer.

  8. CHEK1 loss-of-function mutations have not been found in human tumors, and transgenic expression of Chek1 in mice promotes oncogene (Montrer RAB1A Anticorps)-induced transformation. [review]

  9. persistence of CHK1 levels in response to DNA damage in p53 (Montrer TP53 Anticorps)-deficient cancer cells, leads to CHK1-mediated activation of NF-kappaB (Montrer NFKB1 Anticorps) and induction of NF-kappaB (Montrer NFKB1 Anticorps)-regulated genes in cells and in associated tumor-derived microvesicles, both of which are abrogated by loss or inhibition of CHK1.

  10. Chk1's expression is controlled by p53 (Montrer TP53 Anticorps) and RB/E2F1 (Montrer E2F1 Anticorps) at the transcriptional level.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (Montrer CDC45 Anticorps) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (Montrer DCLRE1C Anticorps) activity of Mre11 (Montrer MRE11A Anticorps), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (Montrer POLK Anticorps)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (Montrer APEX2 Anticorps) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (Montrer APEX2 Anticorps) is essential for Chk1 phosphorylation, indicating a Claspin (Montrer CLSPN Anticorps)-like but distinct role for APE2 (Montrer APEX2 Anticorps) in ATR (Montrer ATR Anticorps)-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (Montrer MAPK1 Anticorps) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Anticorps) and JNK (Montrer MAPK8 Anticorps).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (Montrer TRH Anticorps)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (Montrer CDC25A Anticorps) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan (Montrer SUPT6H Anticorps)-nuclear immunostaining pattern of Histone H2AX.

  2. RAD9 (Montrer RAD9A Anticorps) has a prominent role in the ATR (Montrer ATR Anticorps)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  3. Acute inactivation of E4F1 (Montrer E4F1 Anticorps) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (Montrer ROS1 Anticorps) production, energy stress, and inhibition of de novo pyrimidine synthesis

  4. Altogether, our results classify E4F1 (Montrer E4F1 Anticorps) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  5. Heterozygous loss of Chk1 in a Wnt (Montrer WNT2 Anticorps)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  6. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  7. ATM (Montrer ATM Anticorps) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  8. High level of phospho-Chk1 is associated with skin tumors.

  9. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

  10. activated Akt1 (Montrer AKT1 Anticorps) in Brca1 (Montrer BRCA1 Anticorps)-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 (Montrer RAD51 Anticorps) leading to homologous recombination defects.

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (Montrer NOS3 Anticorps) Ser (Montrer SIGLEC1 Anticorps)(1179) in response to UV irradiation, which is dependent on Hsp90 (Montrer HSP90 Anticorps) interaction.

CHEK1 profil antigène

Antigen Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1) anticorps
  • serine/threonine-protein kinase chk1 (ANI_1_2436074) anticorps
  • serine/threonine-protein kinase chk1 (AOR_1_768154) anticorps
  • serine/threonine-protein kinase Chk1 (PTRG_04183) anticorps
  • serine/threonine-protein kinase chk1 (SJAG_01680) anticorps
  • serine/threonine-protein kinase chk1 (PAAG_04978) anticorps
  • serine/threonine-protein kinase chk1 (MCYG_03290) anticorps
  • serine/threonine-protein kinase chk1 (VDBG_03742) anticorps
  • checkpoint kinase 1 (chek1) anticorps
  • checkpoint kinase 1 (Chek1) anticorps
  • CHK1 checkpoint homolog (S. pombe) (chek1) anticorps
  • CHK1 checkpoint homolog (S. pombe) (CHEK1) anticorps
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A) anticorps
  • An08g10320 anticorps
  • AO090003000441 anticorps
  • C85740 anticorps
  • CHEK1 anticorps
  • Chk1 anticorps
  • id:ibd2720 anticorps
  • rad27 anticorps
  • zgc:56093 anticorps

Protein level used designations for CHEK1

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID SPECIES
100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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