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Human Angiopoietin 2 Kit ELISA pour Sandwich ELISA - ABIN624940
Vizio, Biasi, Scirelli, Novarino, Prati, Ciuffreda, Montrucchio, Poli, Bellone: Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors. dans Journal of translational medicine 2013
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Human Angiopoietin 2 Kit ELISA pour Sandwich ELISA - ABIN414354
Li, Liu, Bin, Wang, Chen, Xiu, Pei, Lai, Chen, Fan, Xie, Tao, Wu: Mutant hypoxia inducible factor-1? improves angiogenesis and tissue perfusion in ischemic rabbit skeletal muscle. dans Microvascular research 2011
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Mouse (Murine) Angiopoietin 2 Kit ELISA pour Sandwich ELISA - ABIN2683446
Bi, Niu, Ding, Zhang, Yang, Gu: Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism. dans Molecular and cellular endocrinology 2016
Shear stress activated Ang-2 via canonical Wnt (Montrer WNT2 Kits ELISA) signaling in vascular endothelial cells, and Wnt (Montrer WNT2 Kits ELISA)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results indicate that the Angpt-Tie2 (Montrer TEK Kits ELISA) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (Montrer TEK Kits ELISA) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 (Montrer TEK Kits ELISA) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (Montrer TIE1 Kits ELISA) in inflammation leads to ANG2 antagonism of Tie2 (Montrer TEK Kits ELISA) and initiates a positive feedback loop wherein FOXO1 (Montrer FOXO1 Kits ELISA)-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1 (Montrer ANGPT1 Kits ELISA)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB (Montrer NME1 Kits ELISA) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (Montrer MLXIP Kits ELISA)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (Montrer ANGPT1 Kits ELISA) and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (Montrer IL18 Kits ELISA) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
We demonstrate that ANGPT2 signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 (Montrer TEK Kits ELISA) receptor and partly directly via tumor cell surface integrin &1.
ANG2 did not affect apoptosis or the cell cycle. In contrast, in the in vivo system, overexpression of ANG2 increased tumor growth.
When Tie2 (Montrer TEK Kits ELISA) becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2 (Montrer TEK Kits ELISA), Angiopoietin-1 (Montrer ANGPT1 Kits ELISA) and Angiopoietin-2, regulate its activation status.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (Montrer IL6 Kits ELISA) (40.2pg/mL), VEGF-A (Montrer VEGFA Kits ELISA) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (Montrer PRAP1 Kits ELISA) (248.1pg/mL), sHER-2/neu (Montrer ERBB2 Kits ELISA) (5010pg/mL) and PLGF (Montrer PGF Kits ELISA) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Gab1/SHP2 (Montrer PTPN11 Kits ELISA)/p38MAPK (Montrer MAPK14 Kits ELISA) signaling pathway and Ang-2 have an essential role in regulating thrombin (Montrer F2 Kits ELISA)-induced monocyte adhesion and vascular leakage
This study demonstrated that ANGPT2 higher expression in glioblastoma.
These observations provide the first evidence for positive regulation of osteogenesis by ANGPT2 in vitro.
in vitro is has also been shown that Angpt-2 can act as a dose-dependent Tie2 (Montrer TEK Kits ELISA) agonist/antagonist.
Ang-2 and sTie-2 plasma levels are increased in pediatric OSA and obesity, particularly when endothelial dysfunction or insulin (Montrer INS Kits ELISA) resistance is detectable.
pathways for two distinctive secretory mechanisms, constitutive and stimulated, of Ang-2 in pulmonary microvascular endothelial cells.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (Montrer ANGPT1 Kits ELISA) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (Montrer HIF1A Kits ELISA) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (Montrer PIK3CA Kits ELISA)/Akt (Montrer AKT1 Kits ELISA) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (Montrer PIK3CA Kits ELISA)/Akt (Montrer AKT1 Kits ELISA) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)