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anti-Human RHEB Anticorps:
anti-Mouse (Murine) RHEB Anticorps:
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Human Polyclonal RHEB Primary Antibody pour IHC, ELISA - ABIN1003087
Yamagata, Sanders, Kaufmann, Yee, Barnes, Nathans, Worley: rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. dans The Journal of biological chemistry 1994
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Human Polyclonal RHEB Primary Antibody pour ELISA, WB - ABIN1003086
Yee, Worley: Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. dans Molecular and cellular biology 1997
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Human Polyclonal RHEB Primary Antibody pour WB - ABIN2476356
Kageyama, Takahashi: Pepsinogens and pepsins from gastric mucosa of Japanese Monkey. Purification and characterization. dans Journal of biochemistry 1976
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Human Monoclonal RHEB Primary Antibody pour ELISA, WB - ABIN519784
Menon, Dibble, Talbott, Hoxhaj, Valvezan, Takahashi, Cantley, Manning: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. dans Cell 2014
By interfering with TSC (Montrer SLC12A3 Anticorps)-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC (Montrer SLC12A3 Anticorps). Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 (Montrer TSC2 Anticorps) from lysosomes and activation of mTORC1.
Data show that Rheb/p27 (Montrer PAK2 Anticorps) axis induces autophagy-dependent cancer cell survival under stress conditions.
Mutations in the TSC2 (Montrer TSC2 Anticorps)-RHEB-mTOR (Montrer FRAP1 Anticorps) signaling axis may lead to a loss of inhibitory inputs thus conferring a survival advantage to a dividing tumor cell.
Activation of CNTF (Montrer CNTF Anticorps)/CNTFRalpha (Montrer CNTFR Anticorps) signaling pathway by hRheb(S16H) transduction of dopaminergic neurons
RGS10 (Montrer RGS10 Anticorps) could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP (Montrer AK3 Anticorps) from Rheb in ovarian cancer cells.
In TSC2 (Montrer TSC2 Anticorps)-deficient angiomyolipoma patient cells, IRF7 (Montrer IRF7 Anticorps) is a pivotal factor in the Rheb/mTOR (Montrer FRAP1 Anticorps) pathway.
These results establish CAD (Montrer CAD Anticorps) as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1 (Montrer RHEBL1 Anticorps))
In vitro data indicated that miR (Montrer MLXIP Anticorps)-155 suppressed the macrophage-mediated bacterial phagocytosis and intracellular killing of Pseudomonas aeruginosa by targeting Rheb (Ras homolog enriched in brain).
Data indicate that Rheb G63A stimulated phosphorylation of the mTORC1 substrate p70S6 kinase more strongly than wild-type, thus offering a new tool for mammalian target of rapamycin (mTOR (Montrer FRAP1 Anticorps)) signaling.
study defines Rheb as a novel physiological regulator of BACE1 (Montrer BACE Anticorps) levels and Abeta (Montrer APP Anticorps) generation, and the Rheb-BACE1 (Montrer BACE Anticorps) circuitry may have a role in brain biology and disease.
Forebrain depletion of Rheb GTPase (Montrer RACGAP1 Anticorps) elicits spatial memory deficits.
Rheb is an important negative regulator of beige (Montrer LYST Anticorps) fat development and thermogenesis. Rheb is able to suppress the beiging effect through an mTORC1-independent mechanism, via PDE4D5-dependent downregulation of the cAMP-PKA signaling pathway.
Rheb and TSC2 (Montrer TSC2 Anticorps) have roles in the mechanical activation of mTOR (Montrer FRAP1 Anticorps) signaling
EAAT4 (Montrer SLC1A6 Anticorps) was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt (Montrer AKT1 Anticorps) was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt (Montrer AKT1 Anticorps) may be related to the downregulation of EAAT4 (Montrer SLC1A6 Anticorps); Rheb1 knockout decreased EAAT4 (Montrer SLC1A6 Anticorps) currents and slowed down the kinetics of AMPA (Montrer GRIA3 Anticorps) currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
Rheb activation disrupts neuronal spine synapse formation via syntenin (Montrer SDCBP Anticorps) accumulation in tuberous sclerosis complex.
We conclude that in contrast to TORC1 (Montrer CRTC1 Anticorps) hyper-activity, cognitive function is not very sensitive to sustained and specific down-regulation of TORC1 (Montrer CRTC1 Anticorps) activity.
Rheb protein was mainly detected in apoptotic retinal ganglion cells following light injury.
PDK4 (Montrer PDK4 Anticorps) promotes tumorigenesis through activation of the CREB (Montrer CREB1 Anticorps)-RHEB-mTORC1 signaling cascade.
The small GTPase (Montrer RACGAP1 Anticorps) Rheb is required for spermatogenesis but not oogenesis.
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Ras homolog enriched in brain
, RAS-homolog enriched in brain
, ras homolog enriched in brain
, GTP-binding protein rheb
, GTP-binding protein Rheb
, Ras homolog enriched in brain 2