Aperçu des produits pour anti-FZD4 (FZD4) Anticorps

Full name:
anti-Frizzled Family Receptor 4 Anticorps (FZD4)
Chez www.anticorps-enligne.fr sont 136 Frizzled Family Receptor 4 (FZD4) Anticorps de 23 de différents fournisseurs disponibles. De plus, nous expédions FZD4 Protéines (15) et FZD4 Kits (9) et beaucoup plus de produits pour cette protéine. Un total de 173 FZD4 produits sont actuellement listés.
Synonymes:
anon-WO0170980.10, anon-WO0170980.11, CD344, CG4626, Dfz4, Dmel\\CG4626, Dm Fz4, EVR1, FEVR, frizzled4, FZ-4, fz1, fz4, FZD4S, FzE4, GPCR, hFz4, zg01

Réactivités les plus populaires pour anti-FZD4 (FZD4) Anticorps

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anti-FZD4 Anticorps mieux référencés

  1. Human Polyclonal FZD4 Primary Antibody pour EIA, WB - ABIN951305 : Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: Severe retinopathy of prematurity associated with FZD4 mutations. dans Ophthalmic genetics 2010 (PubMed)
    Show all 5 references for 951305

  2. Cow (Bovine) Polyclonal FZD4 Primary Antibody pour IHC, WB - ABIN2776715 : Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. dans The American journal of pathology 2008 (PubMed)
    Show all 4 references for 2776715

  3. Human Monoclonal FZD4 Primary Antibody pour FACS, ICC - ABIN4900303 : Baksh, Boland, Tuan: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. dans Journal of cellular biochemistry 2007 (PubMed)
    Show all 2 references for 4900303

  4. Human Polyclonal FZD4 Primary Antibody pour ELISA, WB - ABIN408660 : You, Nguyen, Albers, Lin, Holcombe: Wnt pathway-related gene expression in inflammatory bowel disease. dans Digestive diseases and sciences 2008 (PubMed)

  5. Human Monoclonal FZD4 Primary Antibody pour FACS, ICC - ABIN4898976 : Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. dans Stem cells (Dayton, Ohio) 2012 (PubMed)

Plus d’anticorps contre FZD4 partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (Montrer FZD2 Anticorps) or Tc-fz4 RNAi knockdowns.

Human Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Study shows that WNT5A (Montrer WNT5A Anticorps) stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD (Montrer CRX Anticorps) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (Montrer WNT2 Anticorps) binding through the CRDs and that the Wnt (Montrer WNT2 Anticorps) palmitoleoyl group is important in promoting these interactions.

  2. FZD4 down-regulation leads to loss of WNT (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.

  3. his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway via downregulated Frizzled4.

  4. Among the detected mutations, LRP5 (Montrer LRP5 Anticorps) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (Montrer NDP Anticorps) (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (Montrer TSPAN12 Anticorps) (1/31, 3.2%), and KIF11 (Montrer KIF11 Anticorps) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  5. human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.

  6. Several novel mutations (missense, non-stop (Montrer USP22 Anticorps) and insertion) were detected in the coding regions of FZD4, TSPAN12 (Montrer TSPAN12 Anticorps) and ZNF408 (Montrer ZNF408 Anticorps) genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 and TSPAN12 (Montrer TSPAN12 Anticorps) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.

  7. Two were novel mutations: p.E134* and p.T503fs of FZD4 lead to the loss of FZD4 activity.

  8. Letter: FZD4+ and FZD4- melanocytes were significantly lower in hair follicles of patients with rhododenol-induced leukoderma.

  9. These structural, biophysical and cellular data, map Fz4 and putative Lrp5 (Montrer LRP5 Anticorps)/6 binding sites to distinct patches on Norrin (Montrer NDP Anticorps), and reveal a GAG binding site spanning Norrin (Montrer NDP Anticorps) and Fz4 cysteine-rich domain.

  10. The relatively high prevalence of the p.[P33S(;)P168S] variant in ROP (Montrer STXBP1 Anticorps) (retinopathy of prematurity) and intrauterine growth restriction suggests that it also may be a marker for increased risk of developing ROP (Montrer STXBP1 Anticorps) and preterm birth.

Xenopus laevis Frizzled Family Receptor 4 (FZD4) interaction partners

  1. A splice variant of the Frizzled-4 receptor modulates Wnt (Montrer WNT2 Anticorps) signalling in a dose-dependent, biphasic manner.

Mouse (Murine) Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Fzd4 and Fzd6 (Montrer FZD6 Anticorps) genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency

  2. Study identified a novel Wnt5a (Montrer WNT5A Anticorps)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis

  3. These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.

  4. The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (Montrer NDP Anticorps)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.

  5. Frizzled 4 regulates arterial network organization through noncanonical Wnt (Montrer WNT2 Anticorps)/planar cell polarity signaling.

  6. Frizzled4 wnt (Montrer WNT2 Anticorps) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.

  7. targeted inactivation of the TSK (Montrer FBN1 Anticorps) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (Montrer WNT2B Anticorps) and Fzd4 expression in the developing peripheral eye

  8. These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.

  9. A major role for frizzled 4 and frizzled 8 (Montrer FZD8 Anticorps) in controlling ureteric growth in the developing kidney.

  10. a Norrin (Montrer NDP Anticorps)-Fz4 signaling system plays a central role in vascular development in the eye and ear, and ligands unrelated to Wnts can act through Fz receptors

FZD4 profil antigène

Antigen Summary

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

Alternative names and synonyms associated with FZD4

  • frizzled 4 (fz4) anticorps
  • frizzled homolog 4 (fzd4) anticorps
  • frizzled-4 (Tsp_10376) anticorps
  • frizzled family receptor 4 (FZD4) anticorps
  • frizzled family receptor 4 (Fzd4) anticorps
  • frizzled family receptor 4 (fzd4) anticorps
  • frizzled homolog 4 (Drosophila) (Fzd4) anticorps
  • anon-WO0170980.10 anticorps
  • anon-WO0170980.11 anticorps
  • CD344 anticorps
  • CG4626 anticorps
  • Dfz4 anticorps
  • Dmel\\CG4626 anticorps
  • Dm Fz4 anticorps
  • EVR1 anticorps
  • FEVR anticorps
  • frizzled4 anticorps
  • FZ-4 anticorps
  • fz1 anticorps
  • fz4 anticorps
  • FZD4S anticorps
  • FzE4 anticorps
  • GPCR anticorps
  • hFz4 anticorps
  • zg01 anticorps

Protein level used designations for FZD4

CG4626-PA , CG4626-PB , fz4-PA , fz4-PB , frizzled homolog 1 , frizzled-4 , frizzled homolog 4 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled receptor 4 , fz-4 , rFz4 , frizzled 4 protein , xfz4 , cFz-4 , mFz4

GENE ID SPECIES
31659 Drosophila melanogaster
30363 Danio rerio
10902349 Trichinella spiralis
100231781 Taeniopygia guttata
8322 Homo sapiens
64558 Rattus norvegicus
399192 Xenopus laevis
373887 Gallus gallus
485149 Canis lupus familiaris
14366 Mus musculus
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