FZD4 anticorps (Middle Region)

N° du produit ABIN2776715

Cité dans 3 publications. Cet anticorps anti-FZD4 Polyclonal Lapin (ABIN2776715) détecte spécifiquement FZD4 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval et Cobaye.

Aperçu rapide pour FZD4 anticorps (Middle Region) (ABIN2776715)

Antigène: FZD4 (Frizzled Family Receptor 4 (FZD4))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-FZD4 anticorps

Épitope: Middle Region

Fonction: FZD4 Antibody - middle region

Séquence: GITSGMWIWS AKTLHTWQKC SNRLVNSGKV KREKRGNGWV KPGKGSETVV

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against FZD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human FZD4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41266-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FZD4 (ABIN2776715)

Wang, Pawlak, Johnson, Belknap, Eades, Stack, Cousin, Black: "Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae." dans: PLoS ONE, Vol. 8, Issue 2, pp. e56025, (2013) (PubMed).

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." dans: PLoS ONE, Vol. 7, Issue 4, pp. e35553, (2012) (PubMed).

Gonzalez, Fernandez-Martos, Gonzalez-Fernandez, Arenas, Rodriguez: "Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats." dans: PLoS ONE, Vol. 7, Issue 12, pp. e50793, (2012) (PubMed).

Détails sur FZD4

Antigène: FZD4 (Frizzled Family Receptor 4 (FZD4))

Autre désignation: FZD4

Sujet:

Background Information: FZD4 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Frizzled family receptor 4

Alternative Symbols: Fz4, EVR1, FEVR, Fz-4, FzE4, GPCR, hFz4, CD344, FZD4S

Protein Name: Frizzled-4

Poids moléculaire: 60 kDa

ID gène: 8322

NCBI Accession: NP_036325

UniProt: Q9ULV1

Pathways: Signalisation WNT, Hormone Transport, Sensory Perception of Sound