Aperçu des produits pour LEF1 Protéines (LEF1)

Full name:
Lymphoid Enhancer-Binding Factor 1 Protéines (LEF1)
Chez www.anticorps-enligne.fr sont 7 Lymphoid Enhancer-Binding Factor 1 (LEF1) Protéines de 4 de différents fournisseurs disponibles. De plus, nous expédions LEF1 Anticorps (129) et LEF1 Kits (3) et beaucoup plus de produits pour cette protéine. Un total de 149 LEF1 produits sont actuellement listés.
3000002B05, AI451430, LEF-1, LEF1, TCF1ALPHA, TCF7L3, TCF10
afficher tous les protéines Gène GeneID UniProt
LEF1 16842 P27782
LEF1 161452 Q9QXN1
LEF1 51176 Q9UJU2

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LEF1 Protéines (LEF1) par origine

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LEF1 Protéines mieux référencés

  1. Human LEF1 Protein expressed in Wheat germ - ABIN1309292 : Shimomura, Takasaki, Nomura, Hayashi, Senda: Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. dans Medical molecular morphology 2013 (PubMed)

Plus protéines pour LEF1 partenaires d'interaction

Zebrafish Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Amotl2a (Montrer AMOTL2 Protéines) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (Montrer YAP1 Protéines) and the Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) effector Lef1.

  2. Lef1 has a role in regulating Dusp6 (Montrer DUSP6 Protéines) in formation of the zebrafish posterior lateral line primordium

  3. Nlk2 (Montrer NLK Protéines) is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.

  4. Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.

  5. Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.

  6. Data conclude that lef1-mediated Wnt (Montrer WNT2 Protéines) signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.

  7. Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a (Montrer EHMT2 Protéines) in regulating lef1.

  8. high-affinity binding sites for Tcf (Montrer HNF4A Protéines)/Lef1 within the boz promoter region

  9. Canonical Wnt (Montrer WNT2 Protéines) signaling through Lef1 is required for hypothalamic neurogenesis.

  10. Domain-specific regulation of foxP2 (Montrer FOXP2 Protéines) CNS expression by lef1.

Mouse (Murine) Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Uncovering a Pitx2 (Montrer PITX2 Protéines)-Sox2 (Montrer SOX2 Protéines)-Lef-1 transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.

  2. this study shows that the transcription factors Tcf1 (Montrer HNF1A Protéines) and Lef1 suppress CD4 (Montrer CD4 Protéines)+ T lineage genes in CD8 (Montrer CD8A Protéines)+ T cells through intrinsic histone deacetylase (Montrer HDAC1 Protéines) activity

  3. leukemic stem cells are therefore more sensitive to loss of Tcf1 (Montrer HNF1A Protéines) and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.

  4. Sp5 (Montrer SP5 Protéines)/8 bind directly to GC boxes in Wnt (Montrer WNT2 Protéines) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (Montrer HNF1A Protéines)/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin (Montrer CTNNB1 Protéines) to target gene enhancers.

  5. This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 (Montrer HNF1A Protéines) and LEF1 for the development of all subsets of Natural Killer T cells.

  6. this study gives new insights into transcriptional regulating mechanisms of Wnt (Montrer WNT2 Protéines)-mediated Isl1 (Montrer ISL1 Protéines) expression during cardiomyocyte differentiation.

  7. data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.

  8. These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.

  9. TDG (Montrer TDG Protéines), as a new coactivator, promotes beta-catenin (Montrer CTNNB1 Protéines)/TCFs transactivation and functionally cooperates with CBP (Montrer CREBBP Protéines) in canonical Wnt (Montrer WNT2 Protéines) signaling.

  10. TCF-1 (Montrer HNF1A Protéines) and LEF-1 adopted distinct genetic 'wiring' to promote the CD4 (Montrer CD4 Protéines)(+) T cell fate and establish CD8 (Montrer CD8A Protéines)(+) T cell identity.

Xenopus laevis Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Tcf (Montrer HNF4A Protéines)/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signalling and to trigger tissue-specific responses.

  2. Interaction of Xom and LEF1/TCF (Montrer HNF4A Protéines)-factors is essential for ventral cell fate determination and LEF1/TCF (Montrer HNF4A Protéines) factors may function as a point of convergence to mediate the combined signaling of Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) and BMP4 (Montrer BMP4 Protéines)/Xom pathways during early embryogenesis.

Human Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Data indicate that microRNA miR (Montrer MLXIP Protéines)-27a directly targets GSK-3beta and increases expression of beta-catenin (Montrer CTNNB1 Protéines) and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells.

  2. and CTU1 (Montrer CTU1 Protéines)/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio (Montrer ACAA1 Protéines) tRNA modification, are up-regulated in human breast cancers and sustain metastasis.

  3. EVI1 (Montrer MECOM Protéines) transcription is directly regulated by LEF1/beta-catenin (Montrer CTNNB1 Protéines) complex in myeloid blast crisis of chronic myeloid leukemia (Montrer BCL11A Protéines). Loss of p53 (Montrer TP53 Protéines) function as a key regulator for beta-catenin (Montrer CTNNB1 Protéines)-EVI1 (Montrer MECOM Protéines) in myeloid blast crisis of chronic myeloid leukemia (Montrer BCL11A Protéines).

  4. LEF1 is a sensitive and specific marker for chronic lymphocytic B-cell leukemia

  5. a frequency of 4-9% expression of LEF1 bymantle cell lymphoma

  6. The results suggest a role for beta-catenin (Montrer CTNNB1 Protéines)/LEF1-mediated transcription in both malignant transformation and metastasis of prostate cancer

  7. The results describe a novel mutation in LEF1 causing dysregulation of Wnt/B catenin signaling in eyelid sebaceous cancinoma

  8. LEF-1 and MITF (Montrer MITF Protéines) regulate tyrosinase (Montrer TYR Protéines) gene transcription in vitro via binding to its promoter.

  9. Methylprednisolone can suppress Wnt (Montrer WNT2 Protéines) signaling pathway by down-regulating LEF-1 protein expression in chronic lymphocyte leukemia cells.

  10. Overexpression of LEF1 is a favorable prognostic factor in childhood ALL.

Pig (Porcine) Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.

Profil protéine LEF1

Profil protéine

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with LEF1

  • lymphoid enhancer-binding factor 1 (LEF1)
  • lymphoid enhancer-binding factor 1 (LOC100352691)
  • lymphoid enhancer-binding factor 1 (lef1)
  • lymphocyte enhancer binding factor 1 (lef1)
  • lymphoid enhancer binding factor 1 (Lef1)
  • lymphoid enhancer factor XLEF-1B (lef1)
  • 3000002B05 Protéine
  • AI451430 Protéine
  • LEF-1 Protéine
  • LEF1 Protéine
  • TCF1ALPHA Protéine
  • TCF7L3 Protéine
  • TCF10 Protéine

Protein level used designations for LEF1

lymphoid enhancer binding factor-1 , lymphoid enhancer-binding factor 1 , lymphoid enhancer-binding factor 1-like , etID310027.1 , LEF-1 , lymphoid enhancer binding factor 1 short isoform , T cell-specific transcription factor 1-alpha , TCF1-alpha , lymphiod enhancer binding factor 1 , transcription factor LEF-1 , lymphoid enhancer binding factor 1

461425 Pan troglodytes
695776 Macaca mulatta
100011783 Monodelphis domestica
100352691 Oryctolagus cuniculus
100399759 Callithrix jacchus
100447785 Pongo abelii
100465982 Ailuropoda melanoleuca
100556215 Anolis carolinensis
100593051 Nomascus leucogenys
30701 Danio rerio
16842 Mus musculus
161452 Rattus norvegicus
779101 Xenopus laevis
51176 Homo sapiens
395865 Gallus gallus
478507 Canis lupus familiaris
100170126 Sus scrofa
535399 Bos taurus
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