anti-Souris MBL2 anticorps pour Enzyme Immunoassay

Recommended MBL2 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) Anticorps
  • MBP-C
  • mbl2
  • MBL
  • Ab2-001
  • Ab2-011
  • L-MBP
  • MBL-C
  • COLEC1
  • HSMBPC
  • MBL2D
  • MBP
  • MBP1
  • MBPD
  • pMBP-27
  • MBL1
  • cMBl
  • collectin
  • mannose-binding lectin (protein C) 2, soluble
  • Mannose-binding protein C
  • mannose-binding lectin (protein C) 2, soluble (opsonic defect)
  • mannose-binding lectin (protein C) 2
  • MBL2
  • mbl2
  • Mbl2
Reactivité
Souris
95
21
17
4
4
4
2
2
2
1
1
1
1
1
1
Hôte
Rat
67
39
8
3
Clonalité
Monoclonal
Conjugué
Cet anticorp MBL2 est non-conjugé
9
6
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
108
73
47
20
14
9
8
8
5
4
3
2
1
1
Fournisseur
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N° du produit ABIN1108115
495,00 €
Plus frais de livraison 40,00 € et TVA
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN1108116 EIA WB Rat IgG2a Connectez-vous pour afficher 16A8 2
1 ABIN2725271 EIA WB Rabbit IgG Connectez-vous pour afficher Polyclonal

General

Antigène Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) Anticorps
Reactivité Souris
(95), (21), (17), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Hôte Rat
(67), (39), (8), (3)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp MBL2 est non-conjugé
(9), (6), (2), (2), (2), (2)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(108), (73), (47), (20), (14), (9), (8), (8), (5), (4), (3), (2), (1), (1)
Pubmed 5 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-MBL2 anticorps

Détail du antigène MBL2 Information d'application Stockage References for anti-MBL2 antibody (ABIN1108115) Images
Réactivité croisée (Details) Species reactivity (tested):Mouse
Purification Protein G
Immunogène Purified MBL-C
Clone 14D12
Isotype IgG2a

Détail du antigène MBL2

Détail du produit anti-MBL2 anticorps Information d'application Stockage References for anti-MBL2 antibody (ABIN1108115) Images Haut de la page
Antigène
Autre désignation Mannan Binding Protein (MBL2 Antibody Extrait)
Sujet Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
ID gène 17195
NCBI Accession NP_034906
UniProt P41317
Domaine de recherche Complement Factors, Receptors, Serum/Plasma Proteins, Inflammation
Pathways Système du Complément, Positive Regulation of Immune Effector Process

Information d'application

Détail du produit anti-MBL2 anticorps Détail du antigène MBL2 Stockage References for anti-MBL2 antibody (ABIN1108115) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-MBL2 anticorps Détail du antigène MBL2 Information d'application References for anti-MBL2 antibody (ABIN1108115) Images Haut de la page
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 2 - 8 °C.

References for anti-MBL2 antibody (ABIN1108115)

Détail du produit anti-MBL2 anticorps Détail du antigène MBL2 Information d'application Stockage Images Haut de la page
Background publications

Pumidonming, Walochnik, Dauber, Petry: "Binding to complement factors and activation of the alternative pathway by Acanthamoeba." dans: Immunobiology, Vol. 216, Issue 1-2, pp. 225-33, 2010

Matthijsen, de Winther, Kuipers, van der Made, Weber, Herias, Gijbels, Buurman: "Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice." dans: Circulation, Vol. 119, Issue 16, pp. 2188-95, 2009

Held, Thiel, Loos, Petry: "Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans." dans: Molecular immunology, Vol. 45, Issue 15, pp. 3934-41, 2008

Phaneuf, Lillie, Hayes, Turner: "Binding of mouse mannan-binding lectins to different bacterial pathogens of mice." dans: Veterinary immunology and immunopathology, Vol. 118, Issue 1-2, pp. 129-33, 2007

Liu, Jensen, Hansen, Petersen, Takahashi, Ezekowitz, Hansen, Jensenius, Thiel: "Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses." dans: Scandinavian journal of immunology, Vol. 53, Issue 5, pp. 489-97, 2001

Images

Détail du produit anti-MBL2 anticorps Détail du antigène MBL2 Information d'application Stockage References for anti-MBL2 antibody (ABIN1108115) Haut de la page
Supplier Images
Immunohistochemistry (IHC) image for anti-Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) antibody (ABIN1108115) anti-Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) antibody