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ADAMTS13 Produits

(ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13))
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].

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Catégories ADAMTS13 en vedette

ADAMTS13 Anticorps

High quality antibodies with extensive validation data.

ADAMTS13 Kits ELISA

Reliable ELISA kits for a wide range of species.

ADAMTS13 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ADAMTS13 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (4)
N° du produit ABIN7265440
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
N° du produit ABIN7432937
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
N° du produit ABIN564816
Quantité 50 μL
Fiche technique Fiche technique

ADAMTS13 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6953460
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964600
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964599
Quantité 96 tests
Fiche technique Fiche technique

ADAMTS13 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305888
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7505139
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7392824
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits ADAMTS13

Tati, Kristoffersson, Manea Hedström, Mörgelin, Wieslander, van Kooten, Karpman: "Neutrophil Protease Cleavage of Von Willebrand Factor in Glomeruli - An Anti-thrombotic Mechanism in the Kidney." dans: EBioMedicine, Vol. 16, pp. 302-311, (2017) (PubMed).

Liu, Guo, Zhang, Liu, Wen, Yang, Yang, Liu: "The Expression of Tristetraprolin and Its Relationship with Urinary Proteins in Patients with Diabetic Nephropathy." dans: PLoS ONE, Vol. 10, Issue 10, pp. e0141471, (2016) (PubMed).

Feng, Eyler, Zhang, Maga, Nester, Kroll, Smith, Afshar-Kharghan: "Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome." dans: Blood, Vol. 122, Issue 8, pp. 1487-93, (2013) (PubMed).

Feng, Liang, Cruz, Vu, Zhou, Pemmaraju, Dong, Kroll, Afshar-Kharghan: "The interaction between factor H and Von Willebrand factor." dans: PLoS ONE, Vol. 8, Issue 8, pp. e73715, (2013) (PubMed).

Hershko, Simhadri, Blaisdell, Hunt, Newell, Tseng, Hershko, Choi, Sauna, Wu, Bram, Komar, Kimchi-Sarfaty: "Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat)." dans: The Journal of biological chemistry, Vol. 287, Issue 53, pp. 44361-71, (2012) (PubMed).

Hunt, Geetha, Allen, Hershko, Fathke, Kong, Plum, Struble, Soejima, Friedman, Garfield, Balaji, Kimchi-Sarfaty: "Detection of a secreted metalloprotease within the nuclei of liver cells." dans: Molecular bioSystems, Vol. 7, Issue 6, pp. 2012-8, (2011) (PubMed).

Ganburged, Suda, Saito, Yamazaki, Isokawa, Moriyama: "Dilated capillaries, disorganized collagen fibers and differential gene expression in periodontal ligaments of hypomorphic fibrillin-1 mice." dans: Cell and tissue research, Vol. 341, Issue 3, pp. 381-95, (2010) (PubMed).

Turner, Nolasco, Ruggeri, Moake: "Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage." dans: Blood, Vol. 114, Issue 24, pp. 5102-11, (2009) (PubMed).

Sen, Tyagi, Patibandla, Dean, Tyagi, Roberts, Lominadze: "Fibrinogen-induced endothelin-1 production from endothelial cells." dans: American journal of physiology. Cell physiology, Vol. 296, Issue 4, pp. C840-7, (2009) (PubMed).

Chung, Popova, Jorgensen, Dong, Chandhoke, Bailey, Popov: "Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy." dans: The Journal of biological chemistry, Vol. 283, Issue 15, pp. 9531-42, (2008) (PubMed).

Synonymes et noms alternatifs relatifs à ADAMTS13

ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13), a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13), ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13), ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13), ADAM metallopeptidase with thrombospondin type 1 motif 13 (Adamts13), ADAM-TS13, ADAMTS-13, ADAMTS13, C9orf8, Gm710, vWF-CP, VWFCP

Protein level used designations for ADAMTS13

  • ADAM metallopeptidase with thrombospondin type 1 motif, 13
  • A disintegrin and metalloproteinase with thrombospondin motifs 13
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
  • vWF-cleaving protease
  • von Willebrand factor-cleaving protease
  • ADAM-TS 13
  • ADAM-TS13
  • ADAMTS-13
  • ADAMTS13 isoform IAP-b
  • vWF-CP mRNA for von Willebrand factor-cleaving
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like
  • A disintegrin and metalloproteinase with thrombospondin motifs 13-like
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
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