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ADAMTS4 Produits

(ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Catégories

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008].

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Catégories ADAMTS4 en vedette

ADAMTS4 Anticorps

High quality antibodies with extensive validation data.

ADAMTS4 Kits ELISA

Reliable ELISA kits for a wide range of species.

ADAMTS4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ADAMTS4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (6)
N° du produit ABIN7072947
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
N° du produit ABIN7142886
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB
Validations
  • (1)
  • (3)
N° du produit ABIN391642
Quantité 400 μL
Fiche technique Fiche technique

ADAMTS4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6974698
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (8)
  • (1)
N° du produit ABIN6953462
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rabbit
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6953464
Quantité 96 tests
Fiche technique Fiche technique

ADAMTS4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305903
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305901
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3089861
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits ADAMTS4

Mao, Wu, Zhang, Zhang, Liao, Li, Kang: "MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 1, pp. 38-52, (2018) (PubMed).

Zhou, Lu, Chen, Ge, Chen, Xu, Shi, Dai, Li, Ju, Cao, Qin, Chen, Teng, Jiang: "AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice." dans: Scientific reports, Vol. 7, pp. 43245, (2017) (PubMed).

Pérez-García, Carrión, Gutiérrez-Cañas, González-Álvaro, Gomariz, Juarranz: "VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts." dans: Journal of cellular and molecular medicine, Vol. 20, Issue 4, pp. 678-87, (2016) (PubMed).

Serra, Gallelli, Butrico, Buffone, Caliò, De Caridi, Massara, Barbetta, Amato, Labonia, Mimmi, Iaccino, de Franciscis: "From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases." dans: International wound journal, (2016) (PubMed).

Dai, Chu, Tian, Song, Wang, Zhang, Zhang: "Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs." dans: Osteoarthritis and cartilage, Vol. 24, Issue 6, pp. 1103-12, (2016) (PubMed).

Pérez-García, Gutiérrez-Cañas, Seoane, Fernández, Mellado, Leceta, Tío, Villanueva-Romero, Juarranz, Gomariz et al.: "Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1β and Fibronectin and Contribution to ..." dans: The American journal of pathology, Vol. 186, Issue 9, pp. 2449-61, (2016) (PubMed).

Liu, Tian, Zhou, Wang, Gou, Zhang, Wang, Shen, Zhang, Zhang: "Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat." dans: BMC musculoskeletal disorders, Vol. 16, pp. 342, (2016) (PubMed).

Uluçay, Çam, Bat?r, Sütçü, Bayturan, Demircan: "A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes." dans: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, (2015) (PubMed).

Manferdini, Maumus, Gabusi, Paolella, Grassi, Jorgensen, Fleury-Cappellesso, Noël, Lisignoli: "Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium." dans: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 23, Issue 11, pp. 2045-57, (2015) (PubMed).

Lee, Lee, Gil, Kim, Lee, Kim, Park: "Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases." dans: Archives of pathology & laboratory medicine, Vol. 138, Issue 5, pp. 643-50, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à ADAMTS4

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4), ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4), ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4), 3830423K05, ADAM-TS4, ADAMTS-2, ADAMTS-4, ADAMTS4, ADMP-1, mKIAA0688

Protein level used designations for ADAMTS4

  • A disintegrin and metalloproteinase with thrombospondin motifs 4
  • ADAM-TS 4
  • ADAMTS-4
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
  • aggrecanase-1
  • ADAM-TS4
  • Aggrecanase
  • a disintegrin and metallopeptidase with thrombospondin motifs 4
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
  • ADMP-1
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4
  • A disintegrin and metalloproteinase with thrombospondin motifs 4-like
  • disintegrin and metalloproteinase with thrombospondin motifs 2
  • a disintegrin and metalloproteinase with thrombospondin motifs 4
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