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PPARA anticorps (N-Term)

PPARA Reactivité: Souris, Rat, Chien, Boeuf (Vache), Porc, Hamsters dorés syriens WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN105798
  • Antigène Voir toutes PPARA Anticorps
    PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))
    Épitope
    • 16
    • 16
    • 15
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 100
    • 90
    • 66
    • 18
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Souris, Rat, Chien, Boeuf (Vache), Porc, Hamsters dorés syriens
    Hôte
    • 101
    • 14
    Lapin
    Clonalité
    • 103
    • 12
    Polyclonal
    Conjugué
    • 50
    • 8
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Cet anticorp PPARA est non-conjugé
    Application
    • 101
    • 46
    • 39
    • 39
    • 39
    • 17
    • 13
    • 13
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    This affinity purified antibody is directed against mouse PPAR alpha protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from mouse, rat, bovine, dog, golden hamster and boar sources based on 100% homology for the immunogen sequence. Cross reactivity with PPAR alpha protein from human, chimpanzee and rhesus monkey may also occur as this sequence shows 88% homology (16/18 identities) with the protein from these sources. Cross reactivity with PPAR alpha homologues from other sources has not been determined. No reactivity is expected against other subtypes of PPAR.
    Attributs du produit
    Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and Anti diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
    Purification
    affinity purified
    Stérilité
    Sterile filtered
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1 to 18 of mouse PPAR alpha.
    Immunogen Type: Peptide
    Isotype
    IgG
    Top Product
    Discover our top product PPARA Anticorps primaire
  • Indications d'application
    This affinity purified antibody has been tested for use in ELISA and by western blot. Expect a single band approximately 52 kDa in size corresponding to PPAR alpha by western blot in the appropriate tissue or cell lysate. A 1:200 dilution is suggested for IHC. Specific conditions for reactivity should be optimized by the end user.
    Commentaires

    Gene Name: PPARA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Date de péremption
    12 months
  • Zak, Gelebart, Lai: "Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis." dans: Leukemia, Vol. 24, Issue 8, pp. 1476-86, (2010) (PubMed).

    Plutzky: "Medicine. PPARs as therapeutic targets: reverse cardiology?" dans: Science (New York, N.Y.), Vol. 302, Issue 5644, pp. 406-7, (2003) (PubMed).

    Mukherjee, Jow, Noonan, McDonnell: "Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators." dans: The Journal of steroid biochemistry and molecular biology, Vol. 51, Issue 3-4, pp. 157-66, (1995) (PubMed).

  • Antigène
    PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))
    Autre désignation
    PPAR alpha (PPARA Produits)
    Synonymes
    anticorps NR1C1, anticorps PPAR, anticorps PPARalpha, anticorps hPPAR, anticorps LOC100136415, anticorps PPARALPHA, anticorps nr1c1, anticorps xPPARalpha, anticorps xppara, anticorps 4933429D07Rik, anticorps AW742785, anticorps Nr1c1, anticorps PPAR-alpha, anticorps Ppar, anticorps peroxisome proliferator activated receptor alpha, anticorps peroxisome proliferator-activated receptor alpha, anticorps peroxisome proliferator activated receptor alpha L homeolog, anticorps PPARA, anticorps LOC100136415, anticorps ppara.L, anticorps Ppara, anticorps ppara
    Sujet
    Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and Anti diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
    Synonyms: hPPAR antibody, MGC2237 antibody, MGC2452 antibody, NR1C1 antibody, Nuclear receptor subfamily 1 group C member 1 antibody, Peroxisome Proliferator Activated Receptor alpha antibody, PPAR antibody
    ID gène
    19013, 31543500
    UniProt
    P23204
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C
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