PPARA anticorps (AA 1-468)

N° du produit ABIN1944858

Détail du produit anti-PPARA anticorps

Antigène: PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

Épitope: AA 1-468

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPARA est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This PPARA antibody is generated from a mouse immunized with a recombination protein from the human region of human PPARA.

Clone: 1331CT894-186-143

Isotype: IgG1 kappa

Information d'application

Indications d'application: IF: 1:25. WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PPARA (ABIN1944858)

Cho, Lee, Choi, Yang, Tae Hong, Kim, Yoon: "Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha." dans: Immunopharmacology and immunotoxicology, Vol. 31, Issue 3, pp. 459-67, (2009) (PubMed).

Kobayashi, Kodani, Nozawa, Endo, Sawasaki: "DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system." dans: FEBS letters, Vol. 582, Issue 18, pp. 2737-44, (2008) (PubMed).

Tugwood, Aldridge, Lambe, Macdonald, Woodyatt: "Peroxisome proliferator-activated receptors: structures and function." dans: Annals of the New York Academy of Sciences, Vol. 804, pp. 252-65, (1997) (PubMed).

Mukherjee, Jow, Noonan, McDonnell: "Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators." dans: The Journal of steroid biochemistry and molecular biology, Vol. 51, Issue 3-4, pp. 157-66, (1995) (PubMed).

Détails sur PPARA

Antigène: PPARA (Peroxisome Proliferator-Activated Receptor alpha (PPARA))

Autre désignation: PPARA (PPARA Produits)

Synonymes: anticorps NR1C1, anticorps PPAR, anticorps PPARalpha, anticorps hPPAR, anticorps LOC100136415, anticorps PPARALPHA, anticorps nr1c1, anticorps xPPARalpha, anticorps xppara, anticorps 4933429D07Rik, anticorps AW742785, anticorps Nr1c1, anticorps PPAR-alpha, anticorps Ppar, anticorps peroxisome proliferator activated receptor alpha, anticorps peroxisome proliferator-activated receptor alpha, anticorps peroxisome proliferator activated receptor alpha L homeolog, anticorps PPARA, anticorps LOC100136415, anticorps ppara.L, anticorps Ppara, anticorps ppara

Sujet: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

Poids moléculaire: 52225

ID gène: 5465

UniProt: Q07869

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Hepatitis C