Caspase 2 anticorps (C-Term)

N° du produit ABIN1105674

Cet anticorps anti-Caspase 2 est un anticorps Lapin Polyclonal détectant Caspase 2 dans WB et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Caspase 2 anticorps (C-Term) (ABIN1105674)

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Caspase 2 anticorps

Épitope: C-Term

Specificité: This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human, Rat.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide mapping at the C-terminal of Human Caspase 2 .Remarks: Sequence is identical to the related Rat and Mouse sequence.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Caspase 2

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Autre désignation: Caspase-2

Sujet: Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2

ID gène: 835

NCBI Accession: NP_116764

UniProt: P42575

Pathways: Apoptose, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway