Desmoplakin anticorps

N° du produit ABIN1106984

L’anticorps Lapin Polyclonal anti-Desmoplakin a été validé pour WB, IHC (fro) et EIA. Il convient pour détecter Desmoplakin dans des échantillons de Humain.

Aperçu rapide pour Desmoplakin anticorps (ABIN1106984)

Antigène: Desmoplakin (DSP)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Desmoplakin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Détail du produit anti-Desmoplakin anticorps

Specificité: Reacts with Human 331 kDa Desmoplakin.

Purification: Affinity Chromatography on Protein A

Immunogène: Synthetic peptide derived from an internal domain of Human DP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in distilled water.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Détails sur Desmoplakin

Antigène: Desmoplakin (DSP)

Autre désignation: Desmoplakin

Sujet: Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP

ID gène: 1832

NCBI Accession: NP_001008844

Pathways: Cell-Cell Junction Organization