FAK anticorps (AA 706-1052)

N° du produit ABIN1107179

Détail du produit anti-FAK anticorps

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Épitope: AA 706-1052

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAK est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificité: This antibody detects human, mouse and rat FAK in Western blotting, Immunoprecipitation and immunocytostaining. This antibody detects ~125 kDa of human FAK on Westernblotting with whole cell lysates from human cell line such as HeLa. Since active FAK is highly phosphorylated, position of FAK band on westernblotting may varry with its phosphorylation level.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Protein-A Sepharose

Immunogène: GST fusion protein containing human FAK (residues 706-1052 a.a.)

Clone: 12G4

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 50 % glycerol, without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur FAK

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Autre désignation: FAK1 / PTK2 (PTK2 Produits)

Synonymes: anticorps FADK, anticorps FAK, anticorps FAK1, anticorps FRNK, anticorps PPP1R71, anticorps p125FAK, anticorps pp125FAK, anticorps PTK2, anticorps Fadk, anticorps mKIAA4203, anticorps fak, anticorps fak1a, anticorps ptk2, anticorps ptk2a, anticorps wu:fa18c04, anticorps zgc:66114, anticorps CG10023, anticorps CT28129, anticorps DFAK, anticorps DFak, anticorps DFak56, anticorps Dfak, anticorps Dfak56, anticorps DmFAK, anticorps Dmel\\CG10023, anticorps Fak56, anticorps Fak56D, anticorps fak56, anticorps protein tyrosine kinase 2, anticorps protein tyrosine kinase 2 L homeolog, anticorps PTK2 protein tyrosine kinase 2, anticorps protein tyrosine kinase 2ab, anticorps Focal adhesion kinase, anticorps PTK2, anticorps ptk2.L, anticorps Ptk2, anticorps ptk2ab, anticorps Fak

Sujet: FAK (focal adhesion kinase) is a protein tyrosine kinase which colocalizes with integrin receptors at cell-substratum contact sites (focal adhesions). It is thought that enhanced tyrosine phosphorylation of FAK is important for integrin mediated signaling as well as for other signalings. FAK associates with a number of proteins such as Src, Shc, PI-3 kinase, Grb2, Cas, Cas-L, paxilin and transmamblane proteins, which enables FAK to couple to a variety of different intracellular transduction pathways in adherent and non-adherent cells. FAK is involved in anchorage-dependent survival signal through PI-3 kinase and also may play a role in cell growth, migration, cytoskeletal organization.Synonyms: FADK1, FAK, Focal adhesion kinase 1, Protein-tyrosine kinase 2, pp125FAK

ID gène: 5747

NCBI Accession: NP_722560

UniProt: Q05397

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling