C3 anticorps

N° du produit ABIN1107627

Cet anticorps anti-C3 est un anticorps Rat Monoclonal détectant C3 dans IP et EIA. Adapté pour Humain.

Aperçu rapide pour C3 anticorps (ABIN1107627)

Antigène: C3 (Complement Component 3 (C3))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp C3 est non-conjugé

Application: Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Clone: 9

Détail du produit anti-C3 anticorps

Specificité: The monocolonal antibody 9 reacts with a neoantigen on iC3, iC3b, C3dg and C3g. It recognizes iC3b, C3dg and C3g in plasma. The antibody does not recognize C3 or C3b.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein G

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur C3

Antigène: C3 (Complement Component 3 (C3))

Autre désignation: Complement C3

Sujet: C3g itself however is a small fragment probably not formed in vivo. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g though this does not occur in plasma.Synonyms: Complement C3

ID gène: 718

NCBI Accession: NP_000055

UniProt: P01024

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling