Interferon gamma anticorps (APC)

N° du produit ABIN1107655

Cet anticorps Souris Monoclonal détecte spécifiquement Interferon gamma dans FACS et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour Interferon gamma anticorps (APC) (ABIN1107655)

Antigène: Interferon gamma (IFNG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Interferon gamma est conjugé à/à la APC

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 45-14

Détail du produit anti-Interferon gamma anticorps (APC)

Specificité: The antibody detects human IFN-gamma, a 20-25 kDa glycoprotein expressed by subsets of T cells and NK cells, that have been stimulated by antigens or mitogens (1-4). Other species not tested.

Purification: Affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Détails sur Interferon gamma

Antigène: Interferon gamma (IFNG)

Autre désignation: IFNG / Interferon gamma

Sujet: The immune system reacts to a pathogen by activation of balanced network of the humoral and cellular immune responses. Subsequently the activated condition of the immune system will, after the elimination of the pathogen, be down-regulated to a balanced situation again. Control of the immune response requires efficient communication between the different cells involved in this response. This interaction is provided by cell/cell contact and by a complex array of mediators. Among these mediators cytokines, soluble factors produced by these cells, play an important role. Cytokines can act on other cells locally or distantly, but can be even auto regulating. Cytokines can behave stimulatory or inhibitory, or can even perform both activities, depending on the (pre)activation stage of the target cell. (3, 4) IFN-gamma has antiviral activity and multiple immunoregulatory functions such as upregulation of MHCClass I antigens on monocytes/macrophages and specific adhesion molecules (e.g. ICAM1 and VCAM1) on endothelial cells. IFN-gamma enhances IgG production by activated B cells, displays chemotactic activities, and plays a role in induction of inflammation.Synonyms: IFN-gamma, gamma IFN

ID gène: 3458

NCBI Accession: NP_000610

UniProt: P01579

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy