IL23A anticorps

N° du produit ABIN1107827

L’anticorps anti-IL23A Monoclonal Souris est utilisé pour la détection de IL23A dans des échantillons de Humain. Il a été validé pour IHC (p) et Func.

Aperçu rapide pour IL23A anticorps (ABIN1107827)

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL23A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Clone: B-Z23

Détail du produit anti-IL23A anticorps

Specificité: This antibody recognizes both recombinant and natural IL-23, p19 sub-unit.

Purification: Ion Exchange Chromatography

Stérilité: 0.22 μm filtered

Immunogène: Recombinant Human IL-23 (sub-unit p19)

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free.

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur IL23A

Antigène: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Autre désignation: Interleukin-23 alpha / IL23A

Sujet: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

ID gène: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation