MARCO anticorps (AA 420-431)

N° du produit ABIN1108157

L’anticorps anti-MARCO Monoclonal Souris est utilisé pour la détection de MARCO dans des échantillons de Humain et Boeuf (Vache). Il a été validé pour WB, IP, FACS, IF, IHC (fro) et Func.

Aperçu rapide pour MARCO anticorps (AA 420-431) (ABIN1108157)

Antigène: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Reactivité: Humain, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MARCO est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: PLK-1

Détail du produit anti-MARCO anticorps

Épitope: AA 420-431

Specificité: This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.

Aucune reactivité croisée: Poulet

Réactivité croisée (Details): Species reactivity (tested):Human, Bovine.

Purification: Protein G Chromatography

Immunogène: Human alveolar macrophages

Isotype: IgG3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur MARCO

Antigène: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Autre désignation: MARCO

Sujet: The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure

ID gène: 8685

NCBI Accession: NP_006761

UniProt: Q9UEW3

Pathways: Activation of Innate immune Response