SMAD2 anticorps (N-Term)

N° du produit ABIN1109059

Cet anticorps Lapin Polyclonal détecte spécifiquement SMAD2 dans WB, IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SMAD2 anticorps (N-Term) (ABIN1109059)

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SMAD2 anticorps

Épitope: N-Term

Specificité: This antibody detects SMAD2 (+SMAD3) (N-term). No cross reactivity with other proteins.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogène: Synthetic peptide corresponding to the N-terminal of human SMAD2/3 .Remarks: Sequence is identical to identical to the related mouse and rat sequence.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur SMAD2

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Autre désignation: SMAD2

Sujet: SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Transforming growth factor (TGF)-beta stimulation leads to phosphorylation and activation of Smad2 and Smad3, which form complexes with Smad4 that accumulate in the nucleus and regulate transcription of target genes. Smad2 and Smad3 share highly homology. SMAD2/SMAD3 signal transduction appeared to be important in the regulation of muscle-specific genes. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development.Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development.Synonyms: JV18-1, MAD homolog 2, MADH2, MADR2, Mad-related protein 2, Mothers against DPP homolog 2, Mothers against decapentaplegic homolog 2, SMAD 2, SMAD family member 2, SMAD-2

ID gène: 4087

NCBI Accession: NP_001003652

UniProt: Q15796

Pathways: Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus