Fibrinogen anticorps

N° du produit ABIN110984

L’anticorps Souris Monoclonal anti-Fibrinogen a été validé pour WB et EIA. Il convient pour détecter Fibrinogen dans des échantillons de Humain.

Aperçu rapide pour Fibrinogen anticorps (ABIN110984)

Antigène: Fibrinogen

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fibrinogen est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: FgA

Détail du produit anti-Fibrinogen anticorps

Purification: Gel filtration and anion exchange chromatography

Immunogène: Purified human Fibrinogen

Isotype: IgG1

Information d'application

Indications d'application: ELISA, RIA, westernblot (non-reducing conditions, in this application binds alpha-chain offibrinogen).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 0.5 mL sterile distilled water

Buffer: 10 mM Sodium Phosphate, 0.15 M NaCl, pH 7.4, 0.01 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2-8 °C for one month or (in small aliquots) at -20 °C for longer.

Détails sur Fibrinogen

Antigène: Fibrinogen

Sujet: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease. All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.Synonyms: FGA, FGB, FGG