C3 anticorps

N° du produit ABIN111065

Détail du produit anti-C3 anticorps

Antigène: C3 (Complement Component 3 (C3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Detects C3b deposits in tissue, on cells, on microorganisms and in immune complexes. Does not react with C3a or C3d. Inhibits hemolytic function of C3. It should be used with positive control anti C3b-α (clone H206, cat.no. BM5029), and negative control anti C3a (clone H13, cat.no. BM2131). Activated, deposited C3b bears 3b-α and -ß, but no longer C3a. Ubiquitous or nonspecifically absorbed C3 is still C3a positive with clone H13.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein A affinity chromatography

Immunogène: Human complement component C3

Clone: H11

Isotype: IgG1

Information d'application

Indications d'application: Western Blot. Immunohistochemistry on frozen tissue (Dilution 1: 10, Incubation time: 1h at RT). Successful use on paraffin embedded tissue was reported by some researchers. As thisdetection method has not been verified by antibodies-online, the application was deletedfrom the database. This does not necessarily exclude the use in such procedure.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1 mL dist. water.

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur C3

Antigène: C3 (Complement Component 3 (C3))

Autre désignation: Complement C3 (C3 Produits)

Synonymes: anticorps AHUS5, anticorps ARMD9, anticorps ASP, anticorps C3a, anticorps C3b, anticorps CPAMD1, anticorps AI255234, anticorps HSE-MSF, anticorps Plp, anticorps C3, anticorps C3-1, anticorps sb:cb26, anticorps si:dkey-76b14.4, anticorps wu:fi34b03, anticorps wu:fj86e11, anticorps C3d, anticorps asp, anticorps cpamd1, anticorps c3, anticorps complement C3, anticorps complement component 3, anticorps complement component c3a, duplicate 1, anticorps complement component 3 L homeolog, anticorps complement component C3, anticorps complement C3-like, anticorps C3, anticorps c3a.1, anticorps c3.L, anticorps LOC443475, anticorps c3, anticorps c3-1, anticorps LOC100060539

Sujet: The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3

ID gène: 718

NCBI Accession: NP_000055

UniProt: P01024

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling