C5 anticorps

N° du produit ABIN111066

Cet anticorps anti-C5 est un anticorps Souris Monoclonal détectant C5 dans WB, IHC (fro) et EIA. Adapté pour Humain, Porc, Boeuf (Vache), Chévre et Primate.

Aperçu rapide pour C5 anticorps (ABIN111066)

Antigène: C5 (Complement Component 5 (C5))

Reactivité: Humain, Porc, Boeuf (Vache), Chévre, Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: HCC5b-1 (neo)

Détail du produit anti-C5 anticorps

Specificité: HCC 5b.1 (neo) allows detection of C5b-9 complexes via activated C5, especially in different forms of glomerulonephritis. Does not react with native C5! Polypeptide Reacting: Mr 200 000 polypeptide of SDS denaturated complement component C5 and C5b of Mr 185 000, after C5b activation, an Mr 60 000 cleavage product also reacts (weakly). Disorders Specifically Detected: Detection of C5b-9 complexes via activated C5, whereas native C5 reacts with antibody HCC 5.1.

Réactivité croisée (Details): Species reactivity (tested):Human, Primates, Bovine, Pig, Goat.

Purification: Affinity Chromatography on Protein A

Immunogène: Activated Human Complement Component C5

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Immunoblotting (Western blot). Cytological material. Immunohistochemistry on Frozen Sections (1/10). Incubation time: 1h at RT.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1 mL distilled water.

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur C5

Antigène: C5 (Complement Component 5 (C5))

Autre désignation: Complement C5

Sujet: C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190 kDa glycoprotein consisting of a disulphide linked alpha-chain (111 kDa) and beta-chain (75 kDa). C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain).Synonyms: CPAMD4, Complement Component 5

ID gène: 727

NCBI Accession: NP_001726

UniProt: P01031

Pathways: Système du Complément, Carbohydrate Homeostasis