C5 anticorps
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- Antigène Voir toutes C5 Anticorps
- C5 (Complement Component 5 (C5))
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Reactivité
- Humain, Porc, Boeuf (Vache), Chévre, Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp C5 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
- Specificité
- HCC 5b.1 (neo) allows detection of C5b-9 complexes via activated C5, especially in different forms of glomerulonephritis. Does not react with native C5! Polypeptide Reacting: Mr 200 000 polypeptide of SDS denaturated complement component C5 and C5b of Mr 185 000, after C5b activation, an Mr 60 000 cleavage product also reacts (weakly). Disorders Specifically Detected: Detection of C5b-9 complexes via activated C5, whereas native C5 reacts with antibody HCC 5.1.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Primates, Bovine, Pig, Goat.
- Purification
- Affinity Chromatography on Protein A
- Immunogène
- Activated Human Complement Component C5
- Clone
- HCC5b-1 (neo)
- Isotype
- IgG1
- Top Product
- Discover our top product C5 Anticorps primaire
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- Indications d'application
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ELISA. Immunoblotting (Western blot). Cytological material. Immunohistochemistry on Frozen Sections (1/10). Incubation time: 1h at RT.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Reconstitution
- Restore with 1 mL distilled water.
- Conseil sur la manipulation
- This product is photosensitive and should be protected from light
- Stock
- 4 °C
- Stockage commentaire
- Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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- Antigène
- C5 (Complement Component 5 (C5))
- Autre désignation
- Complement C5 (C5 Produits)
- Synonymes
- anticorps C5, anticorps LOC565774, anticorps C5a, anticorps C5b, anticorps CPAMD4, anticorps Hc, anticorps RGD1561905, anticorps He, anticorps complement C5, anticorps complement component 5, anticorps hemolytic complement, anticorps C5, anticorps c5, anticorps Hc
- Sujet
- C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190 kDa glycoprotein consisting of a disulphide linked alpha-chain (111 kDa) and beta-chain (75 kDa). C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain).Synonyms: CPAMD4, Complement Component 5
- ID gène
- 727
- NCBI Accession
- NP_001726
- UniProt
- P01031
- Pathways
- Système du Complément, Carbohydrate Homeostasis
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