LDLR anticorps

N° du produit ABIN112187

Détail du produit anti-LDLR anticorps

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Humain, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Specificité: Suitable for analysis of LDL Receptor function in patients with familial hypercholesterolemia. The antibody recognizes an epitope in the region of repeat #1 of the ligand binding region. Addition of 15 nM antibody results in inhibition of half-maximal LDL-binding (cf. Beisiegel et al. 1981). In Human normal fibroblasts the antibody detects the 160 kDa polypeptide (pI 4.3) and also in bovine adrenal gland (160 kDa, pI 4.6) of LDL receptors (Beisiegel et al. 1982).

Réactivité croisée (Details): Species reactivity (tested):Human and Bovine.

Purification: Affinity Chromatography

Immunogène: Purified Bovine adrenal cortex LDL Receptor

Clone: C7

Isotype: IgG2b

Information d'application

Indications d'application: FACS. Immunoblotting (Western blotting). Immunofluorescence (1/10-1/50).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1.0 mL distilled water.

Buffer: Final solution contains PBS buffer, pH 7.4 with 0.5 % BSA as stabilizer

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDLR (LDLR Produits)

Synonymes: anticorps FH, anticorps FHC, anticorps LDLCQ2, anticorps Hlb301, anticorps LDLRA, anticorps LDLA, anticorps LDL receptor-2, anticorps fhc, anticorps ldlcq2, anticorps ldlr, anticorps ldlr2-a, anticorps LDL receptor 1, anticorps ldlr-a, anticorps ldlr-b, anticorps low density lipoprotein receptor, anticorps low density lipoprotein receptor a, anticorps low density lipoprotein receptor S homeolog, anticorps low density lipoprotein receptor L homeolog, anticorps LDLR, anticorps Ldlr, anticorps ldlra, anticorps ldlr.S, anticorps ldlr.L

Sujet: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor

ID gène: 3949

NCBI Accession: NP_000518

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism