C3 anticorps (C-Term)

N° du produit ABIN113339

Détail du produit anti-C3 anticorps

Antigène: C3 (Complement Component 3 (C3))

Épitope: C-Term

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp C3 est non-conjugé

Application: Enzyme Immunoassay (EIA)

Specificité: This antibody reacts with Human C3a and C3adesArg (67-76). It does not cross-react with C3 or C4a.

Purification: Affinity Chromatography

Immunogène: Peptide coupled to carrier protein. The antibody was generated against the carboxy-terminal neoepitope which is not exposed on C3, allowing discrimination between C3 and C3a.

Information d'application

Indications d'application: ELISA. The titer with native human C3a was 1: 5000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month. DO NOT FREEZE!

Détails sur C3

Antigène: C3 (Complement Component 3 (C3))

Autre désignation: Complement C3 (C3 Produits)

Synonymes: anticorps AHUS5, anticorps ARMD9, anticorps ASP, anticorps C3a, anticorps C3b, anticorps CPAMD1, anticorps AI255234, anticorps HSE-MSF, anticorps Plp, anticorps C3, anticorps C3-1, anticorps sb:cb26, anticorps si:dkey-76b14.4, anticorps wu:fi34b03, anticorps wu:fj86e11, anticorps C3d, anticorps asp, anticorps cpamd1, anticorps c3, anticorps complement C3, anticorps complement component 3, anticorps complement component c3a, duplicate 1, anticorps complement component 3 L homeolog, anticorps complement component C3, anticorps complement C3-like, anticorps C3, anticorps c3a.1, anticorps c3.L, anticorps LOC443475, anticorps c3, anticorps c3-1, anticorps LOC100060539

Sujet: The complement system is part of the innate immune system representing humoral defence. Activation of the complement cascade via the classical, the alternative or the Lectin pathway liberates several biologically active by-products, among them the anaphylatoxin C3a. Measurement of C3a (and C4a) in plasma or other body fluids can yield important clues about the pathological, and particularly also the inflammatory status of an organism. In serum, C3a activity is under strict control of the carboxypeptidase N. This enzyme rapidly cleaves the C-terminal arginine, thereby generating C3adesArg which shows greatly reduced biological activity as compared to C3a. Thus, the biological activity of C3a is focused mainly on its point of generation, while the degradation product C3adesArg remains relatively stable until it is cleared from the circulation.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3

ID gène: 718

NCBI Accession: NP_000055

UniProt: P01024

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling