alpha 2 Macroglobulin anticorps

N° du produit ABIN113581

Cet anticorps Mouton Polyclonal détecte spécifiquement alpha 2 Macroglobulin dans EIA et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour alpha 2 Macroglobulin anticorps (ABIN113581)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-alpha 2 Macroglobulin anticorps

Specificité: This antibody detects alpha-2-Macroglobulin.

Purification: Ammonium Sulphate fractionation

Immunogène: Native Alpha-2 Macroglobulin

Information d'application

Indications d'application: Immunohistochemistry on frozen sections (1: 20 - 1: 200). ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 28.3 mg/mL

Buffer: PBS, pH 7.2, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: alpha-2-Macroglobulin

Sujet: Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.Synonyms: A2M, Alpha 2 macroglobulin, Alpha-2-M, CPAMD5, PZP-like alpha-2-macroglobulin domain-containing

ID gène: 2

NCBI Accession: NP_000005

UniProt: P01023

Pathways: Lipid Metabolism