Midkine anticorps

N° du produit ABIN115508

Détail du produit anti-Midkine anticorps

Antigène: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Midkine est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Séquence: MKHHHHHHHM KKKDKVKKGG PGSECAEWAW GPCTPSSKDC GVGFREGTCG AQTQRIRCRV PCNWKKEFGA DCKYKFENWG ACDGGTGTKV RQGTLKKARY NAQCQETIRV TKPCTPKTKA KAKAKKGKGK D

Specificité: This antibody reacts to Midkine.

Purification: Immunoaffinity chromatography

Immunogène: Recombinant Human Midkine produced in E.Coli

Information d'application

Indications d'application: ELISA. Western Blot. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 0.05 mL of deionized water

Concentration: 1.0 mg/mL

Buffer: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.

Date de péremption: 6 months

Références pour anticorps anti-Midkine (ABIN115508)

Hara, Ikeda, Shimada, Nagamine, Sawa, Oda: "[Surgical experience of 6 multiple primary lung cancers]" dans: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 61, Issue 3, pp. 183-7, (2008) (PubMed).

Détails sur Midkine

Antigène: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Autre désignation: Midkine (MDK Produits)

Synonymes: anticorps ARAP, anticorps MK, anticorps NEGF2, anticorps Mek, anticorps MK-B, anticorps PTF-alpha-1, anticorps mdk, anticorps midkine, anticorps negf2, anticorps RIHB, anticorps cb518, anticorps fb79b05, anticorps fj33b02, anticorps fj48a12, anticorps mdk2, anticorps plei2, anticorps wu:fb79b05, anticorps wu:fj33b02, anticorps wu:fj48a12, anticorps MK-A, anticorps PTF-alpha-2, anticorps X-PTF-alpha1, anticorps XMK, anticorps mdk-a, anticorps mdk-b, anticorps midkine, anticorps midkine L homeolog, anticorps midkine (neurite growth-promoting factor 2), anticorps midkine b, anticorps midkine S homeolog, anticorps MDK, anticorps Mdk, anticorps mdk.L, anticorps mdkb, anticorps mdk.S

Sujet: Midkine (MK, also called neurite growth promoting factor 2, NEGF-2), a product of a retinoic acid responsive gene, is a secreted 13 kDa protein belonging to the family of heparin binding growth/differentiation factors. MK shares 45 % sequence identity with other member of this family called Pleiotrophin (HB-GAM). Midkine is composed of two domains held together by disulfide linkages. The C-terminally located domain contains two heparin binding sites and is usually responsible for midkine activity. Part of the MK activity is enhanced by dimerization of MK. Midkine has been found in vertebrates from human to zebrafish and is most strongly expresed in midgestation. In the adult MK expression is restricted. In addition to normal development, MK is also involved in the pathogenesis of diseases e.g. inflammatory diseases, human carcinomas such as esophageal, stomach, colon, pancreatic, thyroid, lung, urinary, hepatocellular, neuroblastoma, glioblastoma, Wilm´s tumor etc. High MK levels are associated with poor prognosis in some type of cancer. The increased expresion in many carcinomas indicates that MK can be applied to the diagnosis of malignancy. Midkine is expressed during the reparative stage of bone fractures, also supresses infection of certain viruses including HIV in target cells. Anti-apoptotic and cell protecting activity of midkine makes it to be a promissing in therapy.Synonyms: Amphiregulin-associated protein, MDK, MK, MK1, Midgestation and kidney protein, NEGF2, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein

ID gène: 4192

NCBI Accession: NP_001012333

UniProt: P21741

Pathways: Signalisation RTK, M Phase, Skeletal Muscle Fiber Development