Clusterin anticorps

N° du produit ABIN1169057

L’anticorps anti-Clusterin Polyclonal Lapin est utilisé pour la détection de Clusterin dans des échantillons de Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour Clusterin anticorps (ABIN1169057)

Antigène: Clusterin (CLU)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Clusterin anticorps

Fonction: anti-Clusterin (mouse), pAb

Specificité: Recognizes mouse clusterin. Detects a band of ~48 kDa by Western blot.

Attributs du produit: Polyclonal Antibody. Recognizes mouse clusterin. Detects a band of ~48 kDa by Western blot. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Stérilité: 0.2 μm filtered

Immunogène: Recombinant mouse nuclear clusterin.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Agent conservateur: Without preservative

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: Clusterin

Sujet:

Alternate Names/Synonyms: TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2

Product Description: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

UniProt: Q06890

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling