Clusterin anticorps (Nuclear) (Biotin)

N° du produit ABIN1169058

Cet anticorps anti-Clusterin est un anticorps Lapin Polyclonal détectant Clusterin dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour Clusterin anticorps (Nuclear) (Biotin) (ABIN1169058)

Antigène: Clusterin (CLU)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Clusterin est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA

Détail du produit anti-Clusterin anticorps (Biotin)

Épitope: Nuclear

Specificité: Recognizes human clusterin. Detects a band of ~49 kDa by Western blot.

Réactivité croisée: Humain

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human clusterin (nuclear form).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: Clusterin

Sujet: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling