NLRP6 anticorps

N° du produit ABIN1169061

Cet anticorps anti-NLRP6 Monoclonal Souris (Clone Clint-1) (ABIN1169061) détecte spécifiquement NLRP6 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NLRP6 anticorps (ABIN1169061)

Antigène: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: Clint-1

Détail du produit anti-NLRP6 anticorps

Fonction: anti-NLRP6/NALP6 (human), mAb (Clint-1)

Specificité: Recognizes human NLRP6.

Attributs du produit: Monoclonal Antibody. Recognizes human NLRP6. Isotype: Mouse IgG1kappa. Clone: Clint-1. Applications: IHC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human NLRP6 (NACHT domain).

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur NLRP6

Antigène: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Autre désignation: NLRP6/NALP6

Sujet:

Alternate Names/Synonyms: NACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor, PYRIN-containing APAF1-like Protein 5, NALP6

Product Description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

UniProt: P59044

Pathways: Inflammasome