Caspase 1 (p10) anticorps

N° du produit ABIN1169386

Cet anticorps Souris Monoclonal détecte spécifiquement Caspase 1 (p10) dans WB. Il présente une réactivité avec des échantillons de Souris. Il a été cité dans 6+ publications.

Aperçu rapide pour Caspase 1 (p10) anticorps (ABIN1169386)

Antigène: Caspase 1 (p10) (CASP-1 (p10))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 1 (p10) est non-conjugé

Application: Western Blotting (WB)

Clone: Casper-2

Détail du produit anti-Caspase 1 (p10) anticorps

Fonction: anti-Caspase-1 (p10) (mouse), mAb (Casper-2)

Specificité: Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.

Attributs du produit: Monoclonal Antibody. Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1. Isotype: Mouse IgG2a. Clone: Casper-2. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse caspase-1.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-Caspase 1 (p10) (ABIN1169386)

Chevriaux, Pilot, Derangère, Simonin, Martine, Chalmin, Ghiringhelli, Rébé: "Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction." dans: Frontiers in cell and developmental biology, Vol. 8, pp. 167, (2020) (PubMed).

Liu, Lu, Chen, Muthuraj, Li, Pattabiraman, Zempleni, Kachman, Natarajan, Yu: "Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice." dans: Nutrients, Vol. 12, Issue 2, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." dans: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Wong, Li, Rao, Yang, Cheng, Lin, Cheng, Chen, Hua: "Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome." dans: Frontiers in immunology, Vol. 9, pp. 1920, (2018) (PubMed).

Freeman, Guo, David, Brickey, Jha, Ting: "NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes." dans: The Journal of experimental medicine, Vol. 214, Issue 5, pp. 1351-1370, (2017) (PubMed).

Yabal, Müller, Adler, Knies, Groß, Damgaard, Kanegane, Ringelhan, Kaufmann, Heikenwälder, Strasser, Groß, Ruland, Peschel, Gyrd-Hansen, Jost: "XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation." dans: Cell reports, Vol. 7, Issue 6, pp. 1796-808, (2014) (PubMed).

Détails sur Caspase 1 (p10)

Antigène: Caspase 1 (p10) (CASP-1 (p10))

Autre désignation: Caspase-1 p10

Sujet:

Alternate Names/Synonyms: Interleukin-1beta Convertase, IL-1BC, Interleukin-1beta-converting Enzyme, ICE

Product Description: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

UniProt: P29452