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- Antigène Voir toutes IRF7 Anticorps
- IRF7 (Interferon Regulatory Factor 7 (IRF7))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IRF7 est conjugé à/à la PE
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Application
- Intracellular Staining (ICS)
- Marque
- BD Phosflow™
- Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human IRF-7 Recombinant Protein
- Clone
- K40-321
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product IRF7 Anticorps primaire
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- Commentaires
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BALB/c
- Volume d'échantillon
- 20 μL
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Triggering the interferon antiviral response through an IKK-related pathway." dans: Science (New York, N.Y.), Vol. 300, Issue 5622, pp. 1148-51, (2003) (PubMed).
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Triggering the interferon antiviral response through an IKK-related pathway." dans: Science (New York, N.Y.), Vol. 300, Issue 5622, pp. 1148-51, (2003) (PubMed).
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- Antigène
- IRF7 (Interferon Regulatory Factor 7 (IRF7))
- Autre désignation
- IRF-7 (IRF7 Produits)
- Synonymes
- anticorps wu:fl24c03, anticorps zgc:66043, anticorps zgc:77947, anticorps IRF7, anticorps irf7, anticorps IRF-7H, anticorps IRF7A, anticorps IRF7B, anticorps IRF7C, anticorps IRF7H, anticorps interferon regulatory factor 7, anticorps irf7, anticorps IRF7, anticorps Irf7
- Sujet
- Interferon regulatory factor 7 (IRF-7) is a transcription factor that regulates anti-viral defenses by controlling the induction of type-I interferon (IFN) responses. IRF-7 expression is induced in lymphoid cells by virus infection, as well as by IFN, lipopolysaccharide, and TNF-a. IRF-7 responses are initiated by Toll-like receptors (TLR) or the cytoplasmic protein retinoic acid inducible gene I (RIG-I). Upon TLR activation, it forms cytoplasmic complexes with MyD88, an adaptor in the TLR signaling pathways. The TLR-dependent and RIG-I-dependent pathways activate kinases, such as IKK-e and TBK1, that phosphorylate IRF-7 and induce movement of IRF-7-containing complexes to the nucleus, where it preferentially activates IFN-a promoters. The K40-321 monoclonal antibody recognizes human IRF-7, regardless of phosphorylation status. Our in-house testing is performed on a cell line that has been co-transfected with TBK1 and IRF-7. Phosphorylation of IRF-7 in the transfectants requires virus infection or over-expression of a signaling molecule of the RIG-I pathway, such as TBK1. Phosphorylation of endogenous IRF-7 in untransfected cells has not yet been detected. We confirmed that mAb K40-321 does not cross-react with TBK1 by Western blot analysis using the purified antibody.
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy
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