Integrin beta 2 anticorps

N° du produit ABIN1176955

Détail du produit anti-Integrin beta 2 anticorps

Antigène: Integrin beta 2 (ITGB2)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 2 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Marque: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogène: LFA-1 (CD11a/CD18) from mouse T-cell hybridoma TAM8C41

Clone: GAME-46

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-Integrin beta 2 (ABIN1176955)

Driessens, van Hulten, Zuurbier, La Rivière, Roos: "Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct." dans: Journal of leukocyte biology, Vol. 60, Issue 6, pp. 758-65, (1997) (PubMed).

Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." dans: Cell, Vol. 76, Issue 2, pp. 301-14, (1994) (PubMed).

Springer: "Adhesion receptors of the immune system." dans: Nature, Vol. 346, Issue 6283, pp. 425-34, (1990) (PubMed).

Détails sur Integrin beta 2

Antigène: Integrin beta 2 (ITGB2)

Autre désignation: CD18 (ITGB2 Produits)

Synonymes: anticorps CD18, anticorps LAD, anticorps LCAMB, anticorps LFA-1, anticorps MAC-1, anticorps MF17, anticorps MFI7, anticorps 2E6, anticorps AI528527, anticorps Cd18, anticorps Lfa1, anticorps ITGB2, anticorps itgb2, anticorps itgb2-a, anticorps itgb2-b, anticorps integrin subunit beta 2, anticorps integrin beta 2, anticorps integrin subunit beta 2 S homeolog, anticorps ITGB2, anticorps Itgb2, anticorps itgb2.S

Sujet: The GAME-46 antibody reacts with the common beta2 chain of LFA-1 (CD11a/CD18, alphaLbeta2 integrin), Mac-1 (CD11b/CD18, alphaMbeta2 integrin), and gp150, 95 (CD11c/CD18, alphaXbeta2 integrin). Expression of CD18 is limited to leukocytes, where it is widely distributed in consort with each of the three integrin alpha chains (CD11a, CD11b, and CD11c). Among splenocytes, NK cells have the highest density of CD18, and T lymphocytes express a higher density than the remaining cells. The beta2 integrins are important mediators of leukocyte-endothelium interactions. It has been reported that GAME-46 antibody blocks in vitro adhesion of LFA-1-expressing cells to the ligands ICAM-1, ICAM-2 and ICAM-3 and of Mac-1-expressing cells to ICAM-1, C3bi, and fibrinogen.
Synonyms: Integrin beta2 chain

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation