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Integrin beta 2 anticorps (ITGB2) Primary Antibody

ITGB2 Reactivité: Souris FACS, Func, IHC (f), IHC (p), IP, WB Hôte: Rat Monoclonal M18-2
Pubmed (10)
N° du produit ABIN457404
$317.26
Plus shipping costs $45.00
0.1 mg
local_shipping Destination: Etats-Unis
Envoi sous 5 à 7 jours ouvrables
  • Antigène
    Reactivité
    Souris
    Hôte
    Rat
    Clonalité
    Monoclonal
    Conjugué
    Cet anticorp Integrin beta 2 est non-conjugé
    Application
    Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
    Specificité
    The rat monoclonal antibody M18/2 recognizes CD18 antigen (integrin beta2 subunit, beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.
    Aucune reactivité croisée
    Chien
    Réactivité croisée (Details)
    Mouse
    Purification
    Purified by protein-G affinity chromatography
    Pureté
    > 95 % (by SDS-PAGE)
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogène
    Murine cytotoxic T cell glycoproteins
    Clone
    M18-2
    Isotype
    IgG2a
  • Antigène
    Autre désignation
    CD18 (ITGB2 Antibody Extrait)
    Sujet
    CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 Molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts.
    Pathways
    Signalisation NF-kappaB, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μ,m filter sterilized.
    Agent conservateur
    Azide free
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Cullere, Lauterbach, Tsuboi, Mayadas: "Neutrophil-selective CD18 silencing using RNA interference in vivo." dans: Blood, Vol. 111, Issue 7, pp. 3591-8, 2008 (PubMed).

    Varga, Balkow, Wild, Stadtbaeumer, Krummen, Rothoeft, Higuchi, Beissert, Wethmar, Scharffetter-Kochanek, Vestweber, Grabbe: "Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation." dans: Blood, Vol. 109, Issue 2, pp. 661-9, 2007 (PubMed).

    Watts, Beurskens, Martin-Padura, Ballantyne, Klickstein, Brenner, Lee: "Manifestations of inflammatory arthritis are critically dependent on LFA-1." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 6, pp. 3668-75, 2005 (PubMed).

    Barlow, Langston, Matthews, Chidlow, Kevil: "CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes." dans: The American journal of pathology, Vol. 165, Issue 6, pp. 1849-52, 2004 (PubMed).

    Sakurai, Taguchi, Anand, Ambati, Gragoudas, Miller, Adamis, Ambati: "Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization." dans: Investigative ophthalmology & visual science, Vol. 44, Issue 6, pp. 2743-9, 2003 (PubMed).

    Abraham, Miller: "Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 9, pp. 5193-201, 2001 (PubMed).

    Avni, Pur, Yefenof, Baniyash: "Complement receptor 3 of macrophages is associated with galectin-1-like protein." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 6151-8, 1998 (PubMed).

    Zahalka, Naor: "Beta 2-integrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness." dans: International immunology, Vol. 6, Issue 6, pp. 917-24, 1994 (PubMed).

    Zahalka, Okon, Naor: "Blocking lymphoma invasiveness with a monoclonal antibody directed against the beta-chain of the leukocyte adhesion molecule (CD18)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 10, pp. 4466-77, 1993 (PubMed).

    Sanchez-Madrid, Simon, Thompson, Springer: "Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1." dans: The Journal of experimental medicine, Vol. 158, Issue 2, pp. 586-602, 1983 (PubMed).

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