STAT4 anticorps (pTyr693) (PE)

N° du produit ABIN1177202

L’anticorps Souris Monoclonal anti-STAT4 a été validé pour ICS. Il convient pour détecter STAT4 dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour STAT4 anticorps (pTyr693) (PE) (ABIN1177202)

Antigène: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT4 est conjugé à/à la PE

Application: Intracellular Staining (ICS)

Clone: 38-p

Détail du produit anti-STAT4 anticorps (PE)

Épitope: pTyr693

Marque: BD Phosflow™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Phosphorylated Human Stat4 (pY693)

Isotype: IgG2b kappa

Information d'application

Volume d'échantillon: 5 μL

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.

Références pour anticorps anti-STAT4 (PE) (ABIN1177202)

Kisseleva, Bhattacharya, Braunstein, Schindler: "Signaling through the JAK/STAT pathway, recent advances and future challenges." dans: Gene, Vol. 285, Issue 1-2, pp. 1-24, (2002) (PubMed).

Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." dans: Blood, Vol. 96, Issue 5, pp. 1844-52, (2000) (PubMed).

Détails sur STAT4

Antigène: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Autre désignation: Stat4

Sujet: The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could neither differentiate into Th1 cells nor produce IFN-gamma in response to treatment with IL-12. IFN-gamma plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
Synonyms: Signal transducer and activator of transcription 4, SLEB11

Pathways: Signalistation JAK/STAT