CD47 anticorps
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- Antigène Voir toutes CD47 Anticorps
- CD47
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Reactivité
- Souris
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Hôte
- Rat
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD47 est non-conjugé
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Fluorescence Microscopy (FM)
- Marque
- BD Pharmingen™
- Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- Endotoxin level is ≤ 0.1 EU/μg (≤ 0.01 ng/μg) of protein as determined by the LAL assay.
- Clone
- MIAP301
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CD47 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- Agent conservateur
- Azide free
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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Expression of a synapse-associated membrane protein, P84/SHPS-1, and its ligand, IAP/CD47, in mouse retina." dans: The Journal of comparative neurology, Vol. 416, Issue 3, pp. 335-44, (2000) (PubMed).
: "Role of CD47 as a marker of self on red blood cells." dans: Science (New York, N.Y.), Vol. 288, Issue 5473, pp. 2051-4, (2000) (PubMed).
: "Integrin-associated protein is a ligand for the P84 neural adhesion molecule." dans: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 559-62, (1999) (PubMed).
: "Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice." dans: Science (New York, N.Y.), Vol. 274, Issue 5288, pp. 795-8, (1996) (PubMed).
: "In vivo expression of alternatively spliced forms of integrin-associated protein (CD47)." dans: Journal of cell science, Vol. 108 ( Pt 11), pp. 3419-25, (1996) (PubMed).
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Expression of a synapse-associated membrane protein, P84/SHPS-1, and its ligand, IAP/CD47, in mouse retina." dans: The Journal of comparative neurology, Vol. 416, Issue 3, pp. 335-44, (2000) (PubMed).
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- Antigène
- CD47
- Autre désignation
- CD47 (CD47 Produits)
- Synonymes
- anticorps IAP, anticorps MER6, anticorps OA3, anticorps 9130415E20Rik, anticorps AA407862, anticorps AI848868, anticorps AW108519, anticorps B430305P08Rik, anticorps Itgp, anticorps CD47/IAP, anticorps alkaline phosphatase, intestinal, anticorps CD47 molecule, anticorps CD47 antigen (Rh-related antigen, integrin-associated signal transducer), anticorps Cd47 molecule, anticorps ALPI, anticorps CD47, anticorps Cd47
- Sujet
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The miap301 monoclonal antibody specifically binds to the extracellular domain of CD47, also known as Integrin-Associated Protein (IAP). CD47 is a 50-kDa plasma membrane protein with an extracellular immunoglobulin variable region-like domain, a multiple membrane-spanning segment, and a short C-terminal cytoplasmic tail. IAP is often physically associated with beta3 integrins, and it may act as a transducer element in activation mediated by these integrins. CD47 is expressed by a wide variety of cell types, including some cells lacking integrins, such as erythrocytes. The cytoplasmic tail region is expressed as alternatively spliced forms, which are differentially expressed in diverse tissues, suggesting that IAP may have distinct functions in various tissues. CD47 and its ligand, CD172a, are proposed to mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages.
Synonyms: Cd47, IAP, Integrin-associated protein, Itgp
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