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CD47 anticorps (CD47) (FITC) Primary Antibody

CD47 Reactivité: Humain, Non-Human Primate, Porc FACS, IHC (f), WB Hôte: Souris Monoclonal MEM-122
Pubmed (1)
N° du produit ABIN192129
$455.40
Plus shipping costs $45.00
100 tests
local_shipping Destination: Etats-Unis
Envoi sous 5 à 7 jours ouvrables
  • Antigène
    Reactivité
    Humain, Non-Human Primate, Porc
    Hôte
    Souris
    Clonalité
    Monoclonal
    Conjugué
    Cet anticorp CD47 est conjugé à/à la FITC
    Application
    Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
    Specificité
    The antibody MEM-122 reacts with CD47 (Integrin Associated Protein), a 50-55 kDa membrane adhesion molecule (thrombospondin receptor, immunoglobulin supergene family) expressed on leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines.
    HLDA VI, WS Code AS A051
    Réactivité croisée (Details)
    Non-Human Primates, Human, Porcine
    Immunogène
    COS-7 (African green monkey) cells
    Clone
    MEM-122
    Isotype
    IgM
  • Indications d'application
    The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing Tris buffered saline (TBS) solution containing 15 mM sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Smith, Patel, Seatter, Deehan, Brown, Brooke, Goodridge, Howard, Rigley, Harnett, Harnett: "A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes." dans: Blood, Vol. 102, Issue 7, pp. 2532-40, 2003 (PubMed).

  • Antigène
    Autre désignation
    CD47 (CD47 Antibody Extrait)
    Synonymes
    9130415E20Rik, AA407862, AI848868, AW108519, B430305P08Rik, IAP, Itgp, MER6, OA3, CD47/IAP, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 molecule, Cd47 molecule, Cd47, CD47
    Sujet
    CD47 (integrin-associated protein, IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages, this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
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