CD80 anticorps

N° du produit ABIN1177361

3+ publications sont disponibles pour ce produit. L’anticorps anti-CD80 Monoclonal produit chez le Souris a été validé pour FACS. Il convient pour la détection de CD80 dans des échantillons provenant de Humain. }

Aperçu rapide pour CD80 anticorps (ABIN1177361)

Antigène: CD80

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD80 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: L307-4

Détail du produit anti-CD80 anticorps

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-CD80 (ABIN1177361)

Azuma, Yssel, Phillips, Spits, Lanier: "Functional expression of B7/BB1 on activated T lymphocytes." dans: The Journal of experimental medicine, Vol. 177, Issue 3, pp. 845-50, (1993) (PubMed).

Schwartz: "Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy." dans: Cell, Vol. 71, Issue 7, pp. 1065-8, (1993) (PubMed).

Koulova, Clark, Shu, Dupont: "The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells." dans: The Journal of experimental medicine, Vol. 173, Issue 3, pp. 759-62, (1991) (PubMed).

Détails sur CD80

Antigène: CD80

Autre désignation: CD80

Sujet: The L307.4 monoclonal antibody specifically reacts with B7/BB1, a 60 kDa transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Leukocyte Differentiation Antigens. CD80, a member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells. It is the ligand for two molecules expressed on T cells, CD28 and CD152 (CTLA-4). CD80 is also expressed on activated CD4-positive and CD8-positive T cells, appearing late after activation suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. The binding of CD28 by anti-CD28 or by CD80 results in T-cell activation and a signal for IL-2 production.
Synonyms: B7.1, B7-1, Activation B7-1 antigen, B7, BB1, CD28LG, CD28LG1, LAB7

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints