ITGA2 anticorps

N° du produit ABIN118700

L’anticorps anti-ITGA2 Monoclonal produit chez le Souris a été validé pour FACS. Il convient pour la détection de ITGA2 dans des échantillons provenant de Humain et Singe. }

Aperçu rapide pour ITGA2 anticorps (ABIN118700)

Antigène: ITGA2 (Integrin alpha 2 (ITGA2))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGA2 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: AK7

Détail du produit anti-ITGA2 anticorps

Specificité: This antibody recognises the integrin alpha 2 subunit, which is 160 kDa cell surface antigen expressed by NK cells and a small subset of T-cells. This antibody inhibits cell attachment to collagen.

Purification: Affinity Chromatography on Protein G.

Immunogène: Spleen cells from immunised mice were fused with cells of the mouse NS1 myeloma cell line.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry: 1/50-1/100, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunohistochemistry on Frozen Sections: 1/500-1/1000. Recommended positive control tissue: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ITGA2

Antigène: ITGA2 (Integrin alpha 2 (ITGA2))

Autre désignation: CD49b / ITGA2

Sujet: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.Synonyms: CD49 antigen-like family member B, Collagen Receptor, GPIa, ITGA-2, Integrin alpha-2, Platelet membrane glycoprotein Ia, VLA-2 alpha, VLA2

ID gène: 3673

NCBI Accession: NP_002194

UniProt: P17301

Pathways: CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex