ITGA6 anticorps

N° du produit ABIN118734

Cet anticorps anti-ITGA6 est un anticorps Souris Monoclonal détectant ITGA6 dans FACS. Adapté pour Humain.

Aperçu rapide pour ITGA6 anticorps (ABIN118734)

Antigène: ITGA6 (Integrin, alpha 6 (ITGA6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGA6 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 450-30A

Détail du produit anti-ITGA6 anticorps

Specificité: This antibody recognises the VLA-6 cell surface antigen, also known as the alpha 6 integrin and as CD49f.

Purification: Affinity Chromatography on Protein G.

Immunogène: a6b4 integrin purified from A431 cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1/10 - 1/50, use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunohistochemistry on frozen sections: 1/50 - 1/100. Recommended Positive Control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ITGA6

Antigène: ITGA6 (Integrin, alpha 6 (ITGA6))

Autre désignation: CD49f / ITGA6

Sujet: Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis. CD49f is expressed by platelets, weakly by monocytes and by a subset of lymphocytes. CD49f is also widely expressed on epithelial tissues.Synonyms: CD49 antigen-like family member F, Integrin alpha-6, VLA-6, VLA6

ID gène: 3655

NCBI Accession: NP_000201

UniProt: P23229

Pathways: CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex