CTLA4 anticorps

N° du produit ABIN118890

Cet anticorps anti-CTLA4 Monoclonal Souris (Clone BNI3) (ABIN118890) détecte spécifiquement CTLA4 dans FACS, Func, IHC (fro) et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CTLA4 anticorps (ABIN118890)

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: BNI3

Détail du produit anti-CTLA4 anticorps

Specificité: Highly specific for CD152 (CTAL-4).

Immunogène: Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig)

Isotype: IgG2a

Information d'application

Indications d'application: Research studies by Microscopy or Flow cytometry, after in vitro activation of T cells with selected stimuli (Concanavalin A, or solid-phase fixed-CD3 + CD28 Mabs stimulation). Research studies on CTLA-4 expression on B cells and on CTLA-4 expression by Immunohistochemistry only on frozen tissue sections. Fluorescence microscopy or Flow cytometry: 2 μg/5x10e5 cells/test. Cytospin or immunohistochemistry on frozen tissue sections: Working concentration is 5-50 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1 mL of distilled water.

Buffer: PBS, pH 7.2, containing 1 mg/mL BSA as stabilizer without preservatives

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CD152 / CTLA4

Sujet: The cytolytic T-lymphocyte-associated antigen 4 (CTLA-4) is a member of the Ig superfamily (1) and its extracellular domain exhibits a single Ig V-like region. It was originally identified as a fourth cDNA product, during a search for genes that were thought to be specifically expressed in cytotoxic T lymphocytes (1). CTLA-4 has a molecular weight close to 45 kDa (2). It is mainly expressed as a monomer (4), but may also be expressed as a disulfide-linked homodimer (2,3). CTLA-4 belongs to the CD28 receptor family (4,5).Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

ID gène: 1493

NCBI Accession: NP_001032720

UniProt: P16410

Pathways: Cancer Immune Checkpoints