SOCS3 anticorps

N° du produit ABIN120754

Détail du produit anti-SOCS3 anticorps

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOCS3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody SO1 reacts with SOCS3, an intracellular Cytokine Signaling Inhibitor.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Affinity Chromatography on Protein A

Immunogène: Full-length SOCS3 protein

Clone: 01-11-14

Isotype: IgG2b

Information d'application

Indications d'application: ELISA. Western blot: Use HeLa human cervix carcinoma cell line as positive control. Sample preparation: Resuspend approx. 50 mil. cells in 1 mLcold lysis buffer (1 % laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including protease inhibitor cocktail). Incubate 60 min on ice, centrifuge to remove cell debris. Mix lysate with reducing Laemmli SDS-PAGE sample buffer.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS with 15 mM Sodium Azide as preservative, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Date de péremption: 12 months

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3 / CIS3 (SOCS3 Produits)

Synonymes: anticorps socs3, anticorps fj09e12, anticorps zgc:56537, anticorps wu:fj09e12, anticorps MGC64393, anticorps MGC75749, anticorps xsocs3, anticorps MGC81248, anticorps atod4, anticorps cis3, anticorps cish3, anticorps socs-3, anticorps ssi-3, anticorps ssi3, anticorps SOCS3, anticorps ATOD4, anticorps CIS3, anticorps Cish3, anticorps SOCS-3, anticorps SSI-3, anticorps SSI3, anticorps Cis3, anticorps EF-10, anticorps Ef10, anticorps Ssi3, anticorps Socs-3, anticorps Ssi-3, anticorps suppressor of cytokine signaling 3a, anticorps suppressor of cytokine signaling 3 S homeolog, anticorps suppressor of cytokine signaling 3, anticorps suppressor of cytokine signaling 3 L homeolog, anticorps socs3a, anticorps socs3.S, anticorps socs3, anticorps socs3.L, anticorps SOCS3, anticorps Socs3

Sujet: SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.Synonyms: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3

ID gène: 9021

UniProt: O14543

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C