Serotonin Receptor 4 anticorps (Cytoplasmic Domain)

N° du produit ABIN121987

Cet anticorps Lapin Polyclonal détecte spécifiquement Serotonin Receptor 4 dans IHC (p). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour Serotonin Receptor 4 anticorps (Cytoplasmic Domain) (ABIN121987)

Antigène: Serotonin Receptor 4 (HTR4)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Serotonin Receptor 4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Serotonin Receptor 4 anticorps

Épitope: Cytoplasmic Domain

Specificité: Reacts with 5-HT4 Receptor (family: GPCR, subfamily: Serotonin).

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunohistochemistry with Formalin Fixed Paraffin Embedded Tissues: 6 μg/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0 at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Serotonin Receptor 4

Antigène: Serotonin Receptor 4 (HTR4)

Autre désignation: Serotonin Receptor 4 / HTR4

Sujet: The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library. Ligand: Serotonin.Synonyms: 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4

ID gène: 3360

UniProt: Q13639

Pathways: Signalistation JAK/STAT, cAMP Metabolic Process, S100 Proteins