TNIK anticorps

N° du produit ABIN122435

L’anticorps anti-TNIK Polyclonal Lapin est utilisé pour la détection de TNIK dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour TNIK anticorps (ABIN122435)

Antigène: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNIK est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TNIK anticorps

Specificité: Reacts with Traf2 and NCK-Interacting Kinase (TNIK) (Family: Protein Kinase, Subfamily: MSN)

Réactivité croisée (Details): Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

Purification: Peptide immunogen affinity column

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunocytochemistry. Immunohistochemistry with formalin fixed paraffin embedded tissues: 2 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TNIK

Antigène: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Autre désignation: TNIK

Sujet: TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 (TRAF2) and the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when overexpressed in Phoenix-A cells, and this activation is mediated solely by the C-terminal germinal center kinase homology region. TNIK has been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton. At least eight splice isoforms have been reported. Northern analysis indicates TNIK expression in human heart, skeletal muscle, and brain, with lower levels of expression in kidney, liver, lung, and pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder, skin, and testis and cancerous bone, germ cell, nerve, and placenta.Synonyms: KIAA0551, TRAF2 and NCK-interacting protein kinase

ID gène: 23043

UniProt: Q9UKE5